EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.5 | citrate | - |
Sus scrofa | |
2.1.2.5 | folic acid | - |
Sus scrofa | |
2.1.2.5 | imidazole | - |
Sus scrofa | |
2.1.2.5 | L-glutamate | product inhibition | Sus scrofa | |
2.1.2.5 | Maleate | - |
Sus scrofa | |
2.1.2.5 | N-formiminoaspartate | - |
Sus scrofa | |
2.1.2.5 | Tris | - |
Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.5 | 0.1 | - |
tetrahydrofolate | - |
Sus scrofa | |
2.1.2.5 | 2 | - |
N-formimino-L-glutamate | tetrahydropteroic acid as substrate | Sus scrofa | |
2.1.2.5 | 2.5 | - |
tetrahydropteroic acid | - |
Sus scrofa | |
2.1.2.5 | 12 | - |
N-formimino-L-glutamate | tetrahydrofolate as substrate | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | Sus scrofa | histidine degradation | 5-formiminotetrahydrofolate + L-glutamate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.5 | Sus scrofa | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.1.2.5 | 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate | mechanism | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.2.5 | liver | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.1.2.5 | 43 | 45 | - |
Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.5 | additional information | molecular enzyme complex with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4, both activities are contained in a single polypeptide chain, no substrate: formiminoaspartate | Sus scrofa | ? | - |
? | |
2.1.2.5 | N-formiminoglutamate + tetrahydrofolate | histidine degradation | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | tetrahydrofolate + N-formimino-L-glutamate | tetrahydropteroic acid can replace tetrahydrofolate | Sus scrofa | 5-formiminotetrahydrofolate + L-glutamate | - |
? | |
2.1.2.5 | tetrahydropteroic acid + N-formimino-L-glutamate | tetrahydropteroic acid is a good alternate substrate | Sus scrofa | 5-formiminotetrahydropteroic acid + L-glutamate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.5 | homooctamer | - |
Sus scrofa |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.2.5 | 37 | - |
assay at | Sus scrofa |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.5 | additional information | - |
additional information | 26000 per min per mol or 3250 per min per chain | Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.5 | tetrahydrofolate | folate-dependent enzyme | Sus scrofa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.5 | 0.1 | - |
folic acid | - |
Sus scrofa | |
2.1.2.5 | 0.9 | - |
L-glutamate | - |
Sus scrofa | |
2.1.2.5 | 4 | - |
Tris | - |
Sus scrofa | |
2.1.2.5 | 6 | - |
imidazole | - |
Sus scrofa | |
2.1.2.5 | 10 | - |
formiminoaspartate | - |
Sus scrofa | |
2.1.2.5 | 30 | - |
Maleate | - |
Sus scrofa | |
2.1.2.5 | 60 | - |
citrate | - |
Sus scrofa |