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Literature summary extracted from

  • Rubio, A.; Downs, D.M.
    Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar typhimurium (2002), J. Bacteriol., 184, 2827-2832.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.11 panB gene encoding enzyme is clustered together with other pantothenate biosynthetic genes panC and panD at 3 min of the chromosome map, panBCD operon Salmonella enterica

Protein Variants

EC Number Protein Variants Comment Organism
2.1.2.11 additional information panBp654 mutant with insertion of one GC base pair upstream of the transcription start site results in an optimized panBCD promoter and a 10fold increase in transcription of the pan operon, i.e. an increased expression of panB, which is sufficient to increase pantothenate biosynthesis Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate Salmonella enterica biosynthesis of pantothenate tetrahydrofolate + 2-dehydropantoate
-
 ?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate Salmonella enterica enzyme may be the rate-limiting reaction in pantothenate biosynthesis tetrahydrofolate + 2-dehydropantoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.11 Salmonella enterica
-
 serovar typhimurium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate
-
 Salmonella enterica tetrahydrofolate + 2-dehydropantoate
-
 ?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate biosynthesis of pantothenate Salmonella enterica tetrahydrofolate + 2-dehydropantoate
-
 ?
2.1.2.11 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate enzyme may be the rate-limiting reaction in pantothenate biosynthesis Salmonella enterica tetrahydrofolate + 2-dehydropantoate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.11 5,10-methylenetetrahydrofolate
-
 Salmonella enterica
2.1.2.11 tetrahydrofolate
-
 Salmonella enterica