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Literature summary extracted from

  • Fu, J.C.; Ding, L.; Clarke, S.
    Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli [published erratum appears in J Biol Chem 1992 Jun 5;267(16):11660] (1991), J. Biol. Chem., 266, 14562-14572.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.77 pcm gene sequenced Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.77 cytosol
-
 Escherichia coli 5829
-
2.1.1.77 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.77 24000
-
 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Salmonella enterica subsp. enterica serovar Typhimurium
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Homo sapiens
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Bos taurus
-
 S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate Escherichia coli repair and/or degradation of spontaneously damaged proteins S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.77 Bos taurus
-
 bovine
-
2.1.1.77 Escherichia coli
-
-
-
2.1.1.77 Homo sapiens
-
 human
-
2.1.1.77 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.77
-
 Escherichia coli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.77 brain
-
 Homo sapiens
-
2.1.1.77 brain
-
 Bos taurus
-
2.1.1.77 erythrocyte
-
 Homo sapiens
-
2.1.1.77 erythrocyte
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.77 0.0000069
-
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.77 S-adenosyl-L-methionine + ovalbumin
-
 Escherichia coli S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + ovalbumin
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + ovalbumin
-
 Bos taurus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Escherichia coli S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein D-aspartate
-
 Bos taurus S-adenosyl-L-homocysteine + protein D-aspartate beta-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Salmonella enterica subsp. enterica serovar Typhimurium S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Escherichia coli S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Homo sapiens S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate
-
 Bos taurus S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?
2.1.1.77 S-adenosyl-L-methionine + protein L-isoaspartate repair and/or degradation of spontaneously damaged proteins Escherichia coli S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.77 monomer 1 * 24000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.1.1.77 type II methyltransferase
-
 Escherichia coli
2.1.1.77 type II methyltransferase
-
 Homo sapiens