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Literature summary extracted from

  • Van Loon, J.A.; Weinshilboum, R.M.
    Thiopurine methyltransferase isozymes in human renal tissue (1990), Drug Metab. Dispos., 18, 632-638.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 3,4-dimethoxy-5-hydroxybenzoic acid
-
 Homo sapiens
2.1.1.67 6-Mercaptopurine
-
 Homo sapiens
2.1.1.67 benzoic acid benzoic acid derivatives Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.67 0.00637
-
 S-adenosyl-L-methionine isoenzyme II Homo sapiens
2.1.1.67 0.00722
-
 S-adenosyl-L-methionine isoenzyme I Homo sapiens
2.1.1.67 0.224
-
 6-Mercaptopurine isoenzyme II Homo sapiens
2.1.1.67 0.307
-
 6-Mercaptopurine isoenzyme I Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.67 cytoplasm
-
 Mus musculus 5737
-
2.1.1.67 cytoplasm
-
 Homo sapiens 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.67 30000
-
 2 isozymes, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Mus musculus
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
 human
-
2.1.1.67 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.67 2 isozymes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 kidney
-
 Mus musculus
-
2.1.1.67 kidney
-
 Homo sapiens
-
2.1.1.67 liver
-
 Mus musculus
-
2.1.1.67 liver
-
 Homo sapiens
-
2.1.1.67 lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine immunosuppressant medication Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.67 6.5
-
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.67 0.00802
-
 6-Mercaptopurine isoenzyme II Homo sapiens
2.1.1.67 0.0107
-
 3,4-dimethoxy-5-hydroxybenzoic acid isoenzyme II Homo sapiens
2.1.1.67 0.0113
-
 6-Mercaptopurine isoenzyme I Homo sapiens
2.1.1.67 0.0113
-
 3,4-dimethoxy-5-hydroxybenzoic acid isoenzyme I Homo sapiens