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Literature summary extracted from

  • Ames, M.M.; Selassie, C.D.; Woodson, L.C.; Van Loon, J.A.; Hansch, C.; Weinshilboum, R.M.
    Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates (1986), J. Med. Chem., 29, 354-358.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.67 medicine enzyme activity might represent one factor responsible for variations in the therapeutic or toxic effects of thiopurine and thiopyrimidine drugs used clinically to treat recipients of transplanted kidneys and patients with renal disease such as glomerulonephritis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 3,4,5-triiodobenzoic acid
-
 Homo sapiens
2.1.1.67 3,4-dimethoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3,5-dichlorobenzoic acid
-
 Homo sapiens
2.1.1.67 3,5-dihydroxy-4-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3,5-dimethylbenzoic acid
-
 Homo sapiens
2.1.1.67 3,5-dinitrobenzoic acid
-
 Homo sapiens
2.1.1.67 3-bromo-5-hydroxy-4-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3-chloro-5-hydroxy-4-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3-hydroxy-4,5-dimethoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3-hydroxy-4-methoxy-5-(dimethylamino)benzoic acid
-
 Homo sapiens
2.1.1.67 3-hydroxy-4-methoxy-5-nitrobenzoic acid
-
 Homo sapiens
2.1.1.67 3-hydroxy-4-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 3-hydroxy-5-iodo-4-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 4-hydroxy-3-methoxybenzoic acid
-
 Homo sapiens
2.1.1.67 benzoic acid substituted benzoic acids, benzoic acid compounds, noncompetitive inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.67 additional information
-
 additional information various thiophenols as substrates, Km 0.0008-0.0078 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.67 partially Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte
-
 Homo sapiens
-
2.1.1.67 kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 2-aminothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 2-methylsulfanylphenylamine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-bromothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-bromo-2-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-methoxythiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methoxy-2-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 3-methoxythiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylsulfanyl-3-methoxybenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-(aminomethoxy)thiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-aminomethoxy-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-bromothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-bromo-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-chlorothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-chloro-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-fluorothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-fluoro-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-methoxythiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methoxy-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-methylthiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methyl-4-methylsulfanylbenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-nitrothiophenol
-
 Homo sapiens S-adenosyl-L-homocysteine + 1-methylsulfanyl-4-nitrobenzene
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 4-thiobenzoate
-
 Homo sapiens S-adenosyl-L-homocysteine + 4-methylsulfanyl benzoate
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?