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Literature summary extracted from

  • Remy, C.N.
    Metabolism of thiopyrimidines and thiopurines (1963), J. Biol. Chem., 238, 1078-1084.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 2,3-Dithiopropanol
-
 Mus musculus
2.1.1.67 2,3-Dithiopropanol
-
 Rattus norvegicus
2.1.1.67 2,4-dithiopyrimidine
-
 Mus musculus
2.1.1.67 2,4-dithiopyrimidine
-
 Rattus norvegicus
2.1.1.67 2-amino-6-thiopurine
-
 Mus musculus
2.1.1.67 2-amino-6-thiopurine
-
 Rattus norvegicus
2.1.1.67 2-mercaptoethanol
-
 Mus musculus
2.1.1.67 2-mercaptoethanol
-
 Rattus norvegicus
2.1.1.67 2-methylthio-4-hydroxypyrimidine 1.8 mM, 45% inhibition Mus musculus
2.1.1.67 2-methylthio-4-hydroxypyrimidine 1.8 mM, 45% inhibition Rattus norvegicus
2.1.1.67 2-Methylthiouracil
-
 Mus musculus
2.1.1.67 2-Methylthiouracil
-
 Rattus norvegicus
2.1.1.67 5-methyl-2,4-dithiopyrimidine
-
 Mus musculus
2.1.1.67 5-methyl-2,4-dithiopyrimidine
-
 Rattus norvegicus
2.1.1.67 6-hydroxy-2-thiopurine
-
 Mus musculus
2.1.1.67 6-hydroxy-2-thiopurine
-
 Rattus norvegicus
2.1.1.67 6-methylthiopurine
-
 Mus musculus
2.1.1.67 6-methylthiopurine
-
 Rattus norvegicus
2.1.1.67 glutathione
-
 Mus musculus
2.1.1.67 glutathione
-
 Rattus norvegicus
2.1.1.67 L-cysteine 1.8 mM, 50% inhibition Mus musculus
2.1.1.67 L-cysteine 1.8 mM, 50% inhibition Rattus norvegicus
2.1.1.67 L-homocysteine
-
 Mus musculus
2.1.1.67 L-homocysteine
-
 Rattus norvegicus
2.1.1.67 L-homocysteine thiolactone
-
 Mus musculus
2.1.1.67 L-homocysteine thiolactone
-
 Rattus norvegicus
2.1.1.67 S-adenosyl-L-methionine
-
 Mus musculus
2.1.1.67 S-adenosyl-L-methionine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.67 0.2
-
 6-Thiopurine
-
 Mus musculus
2.1.1.67 1.7
-
 2-Thiouracil
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Mus musculus specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Rattus norvegicus specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Mus musculus Swiss-Webster specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Mus musculus
-
 mouse
-
2.1.1.67 Mus musculus
-
 Swiss-Webster
-
2.1.1.67 Mus musculus Swiss-Webster
-
 Swiss-Webster
-
2.1.1.67 Rattus norvegicus
-
 rat, Sprague-Dawley
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 kidney
-
 Mus musculus
-
2.1.1.67 kidney
-
 Rattus norvegicus
-
2.1.1.67 liver
-
 Mus musculus
-
2.1.1.67 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-amino-6-thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 2-amino-6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-amino-6-thiopurine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2-amino-6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiothymine
-
 Mus musculus S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiothymine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiothymine
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 2-methylthiothymine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiouracil
-
 Mus musculus S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiouracil
-
 Rattus norvegicus S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 2-thiouracil
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + thiouracil-2-S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine preferred substrate Mus musculus S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine preferred substrate Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine preferred substrate Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + 6-methylthiopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiouric acid
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthiouric acid
-
 ?
2.1.1.67 S-adenosyl-L-methionine + 6-thiouric acid
-
 Rattus norvegicus S-adenosyl-L-homocysteine + 6-methylthiouric acid
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Mus musculus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Rattus norvegicus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine Mus musculus Swiss-Webster S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.67 45 56 heat inactivation, 23% of the activity is lost after 20 min at 45°C, 95% activity is lost after 6 min at 56°C Mus musculus
2.1.1.67 45 56 heat inactivation, 23% of the activity is lost after 20 min at 45°C, 95% activity is lost after 6 min at 56°C Rattus norvegicus