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Literature summary extracted from

  • Anderson, A.C.; Perry, K.M.; Freymann, D.M.; Stroud, R.M.
    The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design (2000), J. Mol. Biol., 297, 645-657.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.45 medicine important drug target, fungus causes opportunistic pneumonia infections in immune-compromised patients and is among the leading causes of death of AIDS patients, inhibitors selective for fungal TS over human TS will be greatly beneficial in combating this disease Pneumocystis carinii

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.45
-
 Pneumocystis carinii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Pneumocystis carinii biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism dihydrofolate + dTMP
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Pneumocystis carinii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Pneumocystis carinii dihydrofolate + dTMP
-
 r
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP biosynthesis of thymidylic acid, only de novo source of thymidine, crucial for DNA replication in every organism Pneumocystis carinii dihydrofolate + dTMP
-
 ?