EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 10-formyl-7,8 dihydrofolate-tetra-gamma-L-glutamate | - |
Homo sapiens | |
2.1.1.45 | 10-formyldihydropteroylglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 10-formyldihydropteroylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 10-formyldihydropteroylpentaglutamate | - |
Homo sapiens | |
2.1.1.45 | 10-formyltetrahydrofolate | - |
Rattus norvegicus | |
2.1.1.45 | 10-Formyltetrahydrofolylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 10-Formyltetrahydrofolylmonoglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 10-formyltetrahydropteroylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 10-formyltetrahydropteroylmonoglutamate | - |
Mus musculus | |
2.1.1.45 | 10-formyltetrahydropteroylpolyglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 5,10-methenyltetrahydrofolylhexa-gamma-L-glutamate | - |
Homo sapiens | |
2.1.1.45 | dihydropteroylpentaglutamate | - |
Homo sapiens | |
2.1.1.45 | N10-formyltetrahydrofolate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.00068 | - |
5,10-formyltetrahydropteroylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 0.00074 | - |
5,10-methenyltetrahydropteroylpentaglutamate | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Mus musculus | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | - |
dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Rattus norvegicus | - |
dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Homo sapiens | - |
HeLa cells | - |
2.1.1.45 | Homo sapiens | - |
MCF-7 breast cancer cells | - |
2.1.1.45 | Mus musculus | - |
Ehrlich ascites carcinoma cells | - |
2.1.1.45 | Rattus norvegicus | - |
rat | - |
2.1.1.45 | Rattus norvegicus | - |
H35 hepatoma cells | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.45 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.45 | liver | - |
Mus musculus | - |
2.1.1.45 | liver | - |
Homo sapiens | - |
2.1.1.45 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-formyltetrahydropteroylheptaglutamate + dUMP | - |
Rattus norvegicus | ? | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Mus musculus | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Mus musculus | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Rattus norvegicus | dihydrofolate + dTMP | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolylheptaglutamate + 2'-deoxyuridylate | - |
Rattus norvegicus | 7,8-dihydrofolylheptaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydrofolylpentaglutamate + 2'-deoxyuridylate | - |
Rattus norvegicus | 7,8-dihydrofolylpentaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydropteroylheptaglutamate + 2'-deoxyuridylate | - |
Homo sapiens | 7,8-dihydropteroylheptaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydropteroylheptaglutamate + 2'-deoxyuridylate | - |
Rattus norvegicus | 7,8-dihydropteroylheptaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydropteroylpentaglutamate + 2'-deoxyuridylate | - |
Homo sapiens | 7,8-dihydropteroylpentaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | 5,10-methylenetetrahydropteroylpentaglutamate + 2'-deoxyuridylate | - |
Rattus norvegicus | 7,8-dihydropteroylpentaglutamate + thymidine phosphate | - |
r | |
2.1.1.45 | [6R,S]-5,10-methylenetetrahydropteroylglutamate + 2'-deoxyuridylate | - |
Mus musculus | ? | - |
r |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.45 | 0.0001 | - |
10-Formyltetrahydrofolylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 0.0007 | - |
10-formyldihydropteroylheptaglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 0.0016 | - |
10-formyldihydropteroylpentaglutamate | - |
Homo sapiens | |
2.1.1.45 | 0.0024 | - |
10-Formyltetrahydrofolylmonoglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 0.0075 | - |
10-formyldihydropteroylglutamate | - |
Rattus norvegicus | |
2.1.1.45 | 0.02 | - |
10-formyltetrahydropteroylmonoglutamate | - |
Mus musculus |