Literature summary extracted from

Kanai, F.; Kaneko, T.; Morishima, H.; Isshiki, K.; Takita, T.; Takeuchi, T.; Umezawa, H.
Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex (1985), J. Antibiot., 38, 39-50.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.45	vanoxonin-vanadium	-	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	Mus musculus	-	dihydrofolate + dTMP	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.45	Mus musculus	-	Ehrlich ascites carcinoma cells	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Mus musculus	dihydrofolate + dTMP	-	?
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Mus musculus	dihydrofolate + dTMP	-	r

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Release 2023.1 (January 2023)