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Literature summary extracted from

  • Kalman, T.I.; Goldman, D.
    Inactivation of thymidylate synthetase by a novel mechanism-based enzyme inhibitor: 1-(beta-D-2-deoxyribofuranosyl) 8-azapurin-2-one 5-monophosphate (1981), Biochem. Biophys. Res. Commun., 102, 682-689.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 1-(2'-deoxyribosyl)8-azapurin-2-one 5'-monophosphate
-
Lacticaseibacillus casei
2.1.1.45 1-(beta-D-2'-deoxyribofuranosyl)1,6-dihydro-8-azapurin-2(3H,6H)-one 5'-monophosphate
-
Lacticaseibacillus casei
2.1.1.45 1-(beta-D-2'-Deoxyribofuranosyl)8-azapurin-2-one 5'-monophosphate
-
Lacticaseibacillus casei
2.1.1.45 5-fluoro-2'-deoxyuridylic acid
-
Lacticaseibacillus casei
2.1.1.45 5-nitro-2'-deoxyuridylic acid
-
Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei key function in DNA synthesis, repair and cell division dihydrofolate + dTMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Lacticaseibacillus casei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.45
-
Lacticaseibacillus casei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
r
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP key function in DNA synthesis, repair and cell division Lacticaseibacillus casei dihydrofolate + dTMP
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.45 (+)-methylenetetrahydrofolate
-
Lacticaseibacillus casei

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.45 0.016
-
1-(2'-deoxyribosyl)-8-azapurin-2-one 5'-monophosphate
-
Lacticaseibacillus casei
2.1.1.45 0.12
-
1-(beta-D-2'-deoxyribofuranosyl)-1,6-dihydro-8-azapurin-2(3H,6H)-one 5'-monophosphate
-
Lacticaseibacillus casei