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Literature summary extracted from

  • Carpenter, N.J.
    Properties and inhibition of thymidylate synthetase in Drosophila melanogaster (1974), J. Insect Physiol., 20, 1389-1401.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-fluorouracil
-
 Drosophila melanogaster
2.1.1.45 fluorodeoxyuridine monophosphate
-
 Drosophila melanogaster
2.1.1.45 methotrexate
-
 Drosophila melanogaster
2.1.1.45 trifluoromethyldeoxyuridine 5'-monophosphate
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Drosophila melanogaster
-
 dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Drosophila melanogaster dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Drosophila melanogaster dihydrofolate + dTMP
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.45 7.5 8
-
 Drosophila melanogaster