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Literature summary extracted from

  • Gupta, V.S.; Meldrum, J.B.
    Purification and properties of thymidylate synthetase from pig thymus (1972), Can. J. Biochem., 50, 353-362.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.45 dithiothreitol maximal catalytic activity only in presence of sulfhydryl compounds Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Sus scrofa
-
 dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Sus scrofa
-
 pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.45 thymus
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Sus scrofa dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Sus scrofa dihydrofolate + dTMP
-
 r
2.1.1.45 5,10-methylenetetrahydrofolate + uridine 5'-phosphate
-
 Sus scrofa dihydrofolate + TMP
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.45 6.6 6.8
-
 Sus scrofa
2.1.1.45 7.2 7.4 double pH-optimum in 2-N-morpholinoethane sulfonic acid buffer Sus scrofa