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Literature summary extracted from

  • McManus, R.
    Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine (1962), J. Biol. Chem., 237, 1207-1211.
No PubMed abstract available

General Stability

EC Number General Stability Organism
2.1.1.22 stable on freezing and thawing Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.22 0.09
-
 S-adenosyl-L-methionine
-
 Gallus gallus
2.1.1.22 4
-
 carnosine
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.22 soluble
-
 Gallus gallus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.22 Co2+ inhibitory, reversible by addition of EDTA Gallus gallus
2.1.1.22 Mn2+ inhibitory, reversible by addition of EDTA Gallus gallus
2.1.1.22 Zn2+ inhibitory, reversible by addition of EDTA Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.22 S-adenosyl-L-methionine + carnosine Gallus gallus biosynthesis of anserine S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine Cavia porcellus biosynthesis of anserine S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine Rattus norvegicus biosynthesis of anserine S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine Oryctolagus cuniculus biosynthesis of anserine S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine Felis catus biosynthesis of anserine S-adenosyl-L-homocysteine + anserine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.22 Cavia porcellus
-
-
-
2.1.1.22 Felis catus
-
-
-
2.1.1.22 Gallus gallus
-
 White Rock chick
-
2.1.1.22 Oryctolagus cuniculus
-
-
-
2.1.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.22 partial Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.22 brain low activity Gallus gallus
-
2.1.1.22 brain low activity Cavia porcellus
-
2.1.1.22 brain low activity Rattus norvegicus
-
2.1.1.22 heart low activity Cavia porcellus
-
2.1.1.22 heart low activity Rattus norvegicus
-
2.1.1.22 kidney
-
 Rattus norvegicus
-
2.1.1.22 kidney much lower activity than in muscle Gallus gallus
-
2.1.1.22 kidney much lower activity than in muscle Cavia porcellus
-
2.1.1.22 kidney much lower activity than in muscle Oryctolagus cuniculus
-
2.1.1.22 kidney much lower activity than in muscle Felis catus
-
2.1.1.22 kidney about the same activity as in muscle Gallus gallus
-
2.1.1.22 liver same activity than in muscle Gallus gallus
-
2.1.1.22 liver 20% of activity in muscle Rattus norvegicus
-
2.1.1.22 lung
-
 Cavia porcellus
-
2.1.1.22 lung
-
 Rattus norvegicus
-
2.1.1.22 muscle
-
 Gallus gallus
-
2.1.1.22 muscle
-
 Cavia porcellus
-
2.1.1.22 muscle
-
 Rattus norvegicus
-
2.1.1.22 muscle
-
 Oryctolagus cuniculus
-
2.1.1.22 muscle
-
 Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.22 0.0005
-
 purified enzyme Gallus gallus

Storage Stability

EC Number Storage Stability Organism
2.1.1.22 -20°C, very stable Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.22 S-adenosyl-L-methionine + carnosine
-
 Gallus gallus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine
-
 Cavia porcellus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine
-
 Felis catus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine biosynthesis of anserine Gallus gallus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine biosynthesis of anserine Cavia porcellus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine biosynthesis of anserine Rattus norvegicus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine biosynthesis of anserine Oryctolagus cuniculus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + carnosine biosynthesis of anserine Felis catus S-adenosyl-L-homocysteine + anserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + homocarnosine
-
 Cavia porcellus S-adenosyl-L-homocysteine + homoanserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + homocarnosine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + homoanserine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + L-histidine
-
 Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
 ?
2.1.1.22 S-adenosyl-L-methionine + L-histidine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.22 50
-
 no loss of activity within 5 min in presence of carnosine Gallus gallus
2.1.1.22 50
-
 30% loss of activity when heated for 10 min in presence of carnosine, 70% loss of activity within 3 min in absence of carnosine Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.22 7.5 8.5
-
 Gallus gallus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.22 6 9
-
 Gallus gallus