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Literature summary extracted from

  • Shen, R.S.
    Inhibition of dihydropteridine reductase by catecholamines and related compounds (1983), Biochim. Biophys. Acta, 743, 129-135.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 3-iodotyrosine weak inhibition Homo sapiens
1.5.1.34 3-O-methyldopamine 0.06 mM, 50% inhibition Homo sapiens
1.5.1.34 3-O-Methylepinephrine 0.18 mM, 50% inhibition Homo sapiens
1.5.1.34 4-O-Methyldopamine 0.069 mM, 50% inhibition Homo sapiens
1.5.1.34 5-Hydroxydopamine 0.042 mM, 50% inhibition Homo sapiens
1.5.1.34 6-Hydroxydopamine 0.029 mM, 50% inhibition Homo sapiens
1.5.1.34 alpha-Methyltyrosine 1.1 mM, 50% inhibition Homo sapiens
1.5.1.34 catecholamine
-
Homo sapiens
1.5.1.34 dopamine
-
Homo sapiens
1.5.1.34 epinephrine 0.13 mM, 50% inhibition Homo sapiens
1.5.1.34 L-beta-3,4-dihydroxyphenylalanine 0.02 mM, 50% inhibition Homo sapiens
1.5.1.34 L-tyrosine 0.44 mM, 50% inhibition Homo sapiens
1.5.1.34 N-Methyldopamine 0.027 mM, 50% inhibition Homo sapiens
1.5.1.34 norepinephrine 0.2 mM, 50% inhibition Homo sapiens
1.5.1.34 octopamine 0.19 mM, 50% inhibition Homo sapiens
1.5.1.34 tyramine IC50: 0.04 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 liver
-
Homo sapiens
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.34 0.007
-
dopamine noncompetitive vs. NADH Homo sapiens
1.5.1.34 0.014
-
dopamine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.016
-
norepinephrine noncompetitive vs. NADH Homo sapiens
1.5.1.34 0.024
-
tyramine noncompetitive vs. NADH Homo sapiens
1.5.1.34 0.024
-
6-Hydroxydopamine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH Homo sapiens
1.5.1.34 0.05
-
tyramine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.11
-
epinephrine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
1.5.1.34 0.14
-
epinephrine noncompetitive vs. NADH Homo sapiens
1.5.1.34 0.19
-
norepinephrine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.5.1.34 0.04
-
IC50: 0.04 mM Homo sapiens tyramine