EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.33 | pharmacology | successful antifolate chemotherapy in Leishmania will have to target simultaneously both pterine reductase 1 and dihydrofolate reductase-thymidylate synthase | Leishmania major |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.33 | dihydrobiopterin | substrate inhibition | Leishmania major | |
1.5.1.33 | dihydrofolate | substrate inhibition | Leishmania major | |
1.5.1.33 | additional information | - |
Leishmania major |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.33 | 0.012 | - |
NADPH | NADPH | Leishmania major |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.5.1.33 | 30000 | - |
4 * 30000 | Leishmania major |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.33 | Leishmania major | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.5.1.33 | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ | ordered sequential reaction mechanism | Leishmania major |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.33 | Biopterin + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
1.5.1.33 | Dihydrobiopterin + NADPH | - |
Leishmania major | ? | - |
? | |
1.5.1.33 | Dihydrofolate + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrofolate + NADP+ | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.5.1.33 | tetramer | 4 * 30000 | Leishmania major |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.33 | 4.7 | - |
biopterin as substrate | Leishmania major |
1.5.1.33 | 6 | - |
folate as substrate | Leishmania major |