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Literature summary extracted from

  • Sun, S.; Zabinski, R.F.; Toney, M.D.
    Reactions of alternate substrates demonstrate stereoelectronic control of reactivity in dialkylglycine decarboxylase (1998), Biochemistry, 37, 3865-3875.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.64 Gly competitive against 2-aminoisobutanoate Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.64 Burkholderia cepacia
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.64 2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine model in which the interaction between a carboxylate group in the B subsite and Arg406 is a prerequisite to proton donation to and removal from Calpha Burkholderia cepacia
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.64 1-Amino-1-cyclohexane-carboxylate + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 1-Amino-1-cyclopentane-carboxylate + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 2-Aminoisobutanoate + pyruvate
-
 Burkholderia cepacia L-Ala + acetone + CO2
-
 ?
4.1.1.64 alpha-Aminomalonate + pyruvate nonoxidative decarboxylation Burkholderia cepacia Gly + ? + CO2
-
 ?
4.1.1.64 alpha-Aminomalonate + pyruvate + O2
-
 Burkholderia cepacia Ala + ? + CO2
-
 ?
4.1.1.64 D-Ala + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 Gly + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 Isopropylamine + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 L-Ala + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 L-Phenylglycine + pyruvate
-
 Burkholderia cepacia L-Ala + ? + CO2
-
 ?
4.1.1.64 Pyruvate + Gly
-
 Burkholderia cepacia ?
-
 ?
4.1.1.64 Pyruvate + isopropylamine
-
 Burkholderia cepacia ?
-
 ?
4.1.1.64 Pyruvate + L-Ala
-
 Burkholderia cepacia ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.64 0.0012
-
 Gly with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia
4.1.1.64 0.025
-
 alpha-aminomalonate with pyruvate as cosubstrate, oxidative decarboxylation Burkholderia cepacia
4.1.1.64 0.033
-
 L-Ala with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia
4.1.1.64 0.2
-
 D-Ala with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia
4.1.1.64 0.98
-
 1-amino-1-cyclopentanecarboxylate with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia
4.1.1.64 2.3
-
 1-amino-1-cyclohexanecarboxylate with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia
4.1.1.64 25
-
 2-aminoisobutanoate with pyruvate as cosubstrate, decarboxylation Burkholderia cepacia