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Literature summary extracted from
- CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme (1997), Biochem. J., 322, 297-302.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.1.1.50 | pharmacology | potential target for therapeutic agents against various parasitic diseases and proliferating disorders | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.50 | 4-Amidinoindan-1-(2'-amidino)hydrazone | - |
Mus musculus |  |
| 4.1.1.50 | aminoguanidine | irreversible | Mus musculus | |
| 4.1.1.50 | methylglyoxal bis(guanylhydrazone) | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.50 | S-adenosyl-L-methionine | Mus musculus | major regulatory enzyme in polyamine biosynthesis | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.50 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.50 | L-1210 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.50 | S-adenosyl-L-methionine | - |
Mus musculus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| 4.1.1.50 | S-adenosyl-L-methionine | major regulatory enzyme in polyamine biosynthesis | Mus musculus | ? | - |
? | |
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Release 2023.1 (January 2023)
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