Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shantz, L.M.; Stanley, B.A.; Secrist III, J.A.; Pegg, A.E.
    Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine (1992), Biochemistry, 31, 6848-6855.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 pyruvate cofactor Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.50 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine irreversible Homo sapiens
4.1.1.50 5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine irreversible; the inhibitor leads to transamination of the pyruvate prosthetic group Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.50 large-scale Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.50 1.992
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?