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Literature summary extracted from

  • Potts, J.M.; Drapeau, G.R.
    Partial characterization of phosphoribosyl transferase, phosphoribosyl anthranilate isomerase, and indole glycerol phosphate synthase from Serratia marcescens (1972), J. Bacteriol., 111, 334-339.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.48 48000
-
 gel filtration Serratia marcescens
5.3.1.24 48000
-
 indole-3-glycerol-phosphate synthetase/PRA isomerase complex, gel filtration Serratia marcescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate Serratia marcescens involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate Serratia marcescens HY involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.48 Serratia marcescens
-
 bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase, Ec4.1.1.48/Ec5.3.1.24
-
5.3.1.24 Serratia marcescens
-
-
-
5.3.1.24 Serratia marcescens
-
 bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-
5.3.1.24 Serratia marcescens HY
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.48 bifunctional enzyme phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase Serratia marcescens
5.3.1.24 indole-3-glycerol-phosphate synthetase/PRA isomerase complex, 70fold Serratia marcescens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.48 300
-
-
 Serratia marcescens
5.3.1.24 5.5
-
 37°C, indole-3-glycerol-phosphate synthetase/PRA isomerase complex Serratia marcescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.48 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
 Serratia marcescens 1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
 ?
4.1.1.48 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
-
 Serratia marcescens HY 1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Serratia marcescens 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Serratia marcescens 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Serratia marcescens HY 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Serratia marcescens HY 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.48 monomer 1 * 48000, SDS-PAGE Serratia marcescens
5.3.1.24 monomer 1 * 48000, indole-3-glycerol-phosphate synthetase/PRA isomerase complex, SDS-PAGE Serratia marcescens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.3.1.24 37
-
 assay at Serratia marcescens