Literature summary extracted from

Nishizuka, Y.; Ichiyama, A.; Hayaishi, O.
II. Picolinic carboxylase (cat liver) (alpha-amino-beta-carboxymuconic-epsilon-semialdehyde beta-decarboxylase) (1970), Methods Enzymol., 17A, 471-476.

No PubMed abstract available

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.1.1.45	CuSO4	-	Felis catus
4.1.1.45	EDTA	-	Felis catus
4.1.1.45	HgCl2	-	Felis catus
4.1.1.45	NaF	-	Felis catus
4.1.1.45	PCMB	inhibition is prevented by either reduced glutathione or caseine	Felis catus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.1.1.45	0.001	-	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Felis catus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
4.1.1.45	MgCl2	slightly stimulates	Felis catus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.45	Felis catus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
4.1.1.45	-	Felis catus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.1.1.45	liver	-	Felis catus	-

Storage Stability

EC Number	Storage Stability	Organism
4.1.1.45	-20°C, stable for several months	Felis catus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.1.45	2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Felis catus	2-aminomuconate semialdehyde + CO2	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.1.1.45	6	9.5	-	Felis catus

pH Stability

EC Number	pH Stability	pH Stability Maximum	Comment	Organism
4.1.1.45	6	9.5	stable	Felis catus

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Release 2023.1 (January 2023)