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Literature summary extracted from

  • Roberts, A.G.; Elder, G.H.
    Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes (1997), Methods Enzymol., 281, 349-355.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.37 Reducing agents required Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.37 5,5'-dithiobis(2-nitrobenzoate)
-
 Homo sapiens
4.1.1.37 Butanedione
-
 Homo sapiens
4.1.1.37 Cu2+
-
 Homo sapiens
4.1.1.37 diethyldicarbonate reversed by hydroxylamine Homo sapiens
4.1.1.37 Hg2+
-
 Homo sapiens
4.1.1.37 NEM prior incubation with 5-COOH-porphyrinogen III prevents inactivation Homo sapiens
4.1.1.37 PCMB
-
 Homo sapiens
4.1.1.37 Phenylglyoxal
-
 Homo sapiens
4.1.1.37 Pt2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.37 0.00005
-
 5-COOH-porphyrinogen III
-
 Homo sapiens
4.1.1.37 0.00007
-
 5-COOH-porphyrinogen I
-
 Homo sapiens
4.1.1.37 0.00035
-
 uroporphyrinogen III
-
 Homo sapiens
4.1.1.37 0.0008
-
 Uroporphyrinogen I
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.37 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.37 40831
-
 x * 40831, calculation from nucleotide sequence Homo sapiens
4.1.1.37 58000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.37 additional information Homo sapiens enzyme of the heme biosynthetic pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.37 Homo sapiens
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
4.1.1.37 rapid inactivation by uroporphyrin-catalyzed photooxidation Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.37
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.37 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.37 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.37 5-COOH-porphyrinogen I
-
 Homo sapiens Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 5-COOH-porphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + CO2
-
 ?
4.1.1.37 additional information enzyme of the heme biosynthetic pathway Homo sapiens ?
-
 ?
4.1.1.37 uroporphyrinogen I
-
 Homo sapiens coproporphyrinogen I + 4 CO2
-
 ?
4.1.1.37 Uroporphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + 4 CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.37 ? x * 40831, calculation from nucleotide sequence Homo sapiens
4.1.1.37 ? x * 39500-41000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.37 5.4
-
-
 Homo sapiens
4.1.1.37 6.2
-
-
 Homo sapiens
4.1.1.37 6.8
-
 with uroporphyrinogen III or 5-COOH-porphyrinogen III as substrate Homo sapiens