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Literature summary extracted from

  • Axelrod, J.
    Histamine N-methyltransferase (pig liver) (1971), Methods Enzymol., 17, 766-769.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 2-Bromolysergic acid diethylamide
-
 Cavia porcellus
2.1.1.8 chlorpromazine
-
 Cavia porcellus
2.1.1.8 chlorpromazine
-
 Sus scrofa
2.1.1.8 Methylhistamine
-
 Cavia porcellus
2.1.1.8 Methylhistamine
-
 Sus scrofa
2.1.1.8 p-chloromercuribenzoate
-
 Cavia porcellus
2.1.1.8 serotonin
-
 Cavia porcellus
2.1.1.8 serotonin
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.8 0.035
-
 histamine
-
 Cavia porcellus
2.1.1.8 0.38
-
 S-adenosyl-L-methionine
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Cavia porcellus
-
-
-
2.1.1.8 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.8
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 liver
-
 Cavia porcellus
-
2.1.1.8 liver
-
 Sus scrofa
-
2.1.1.8 spleen
-
 Cavia porcellus
-
2.1.1.8 spleen
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.8 10.4
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine highly specific for histamine Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine highly specific for histamine Sus scrofa S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.8 37
-
 assay at Cavia porcellus
2.1.1.8 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 7.2 7.4
-
 Cavia porcellus
2.1.1.8 7.2 7.4
-
 Sus scrofa