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Literature summary extracted from

  • Brown, D.D.; Tomchick, R.; Axelrod, J.
    The distribution and properties of a histamine-methylating enzyme (1959), J. Biol. Chem., 234, 2948-2950.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 2-Bromolysergic acid diethylamide
-
 Cavia porcellus
2.1.1.8 bromo-lysergic acid diethylamide 55% inhibition at 0.005 mM Cavia porcellus
2.1.1.8 Bufotenine
-
 Cavia porcellus
2.1.1.8 chlorpromazine 60% inhibition at o.oo5 mM Cavia porcellus
2.1.1.8 chlorpromazine
-
 Felis catus
2.1.1.8 chlorpromazine
-
 Mus musculus
2.1.1.8 chlorpromazine
-
 Oryctolagus cuniculus
2.1.1.8 chlorpromazine
-
 Rattus norvegicus
2.1.1.8 Methylhistamine 40% inhibition at 0.1 mM Cavia porcellus
2.1.1.8 Methylhistamine
-
 Rattus norvegicus
2.1.1.8 p-chloromercuribenzoate 90% inhibition at 0.01 mM Cavia porcellus
2.1.1.8 p-chloromercuribenzoate
-
 Rattus norvegicus
2.1.1.8 serotonin 33% inhibition at 0.005 mM Cavia porcellus
2.1.1.8 serotonin
-
 Felis catus
2.1.1.8 serotonin
-
 Mus musculus
2.1.1.8 serotonin
-
 Oryctolagus cuniculus
2.1.1.8 serotonin
-
 Rattus norvegicus
2.1.1.8 Tubocurare
-
 Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.8 0.035
-
 histamine
-
 Cavia porcellus
2.1.1.8 0.38
-
 S-adenosyl-L-methionine
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.8 soluble
-
 Cavia porcellus
-
-
2.1.1.8 soluble
-
 Mus musculus
-
-
2.1.1.8 soluble
-
 Rattus norvegicus
-
-
2.1.1.8 soluble
-
 Oryctolagus cuniculus
-
-
2.1.1.8 soluble
-
 Felis catus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.8 additional information Cavia porcellus major pathway of histamine metabolism in mammals ?
-
 ?
2.1.1.8 additional information Mus musculus major pathway of histamine metabolism in mammals ?
-
 ?
2.1.1.8 additional information Rattus norvegicus major pathway of histamine metabolism in mammals ?
-
 ?
2.1.1.8 additional information Oryctolagus cuniculus major pathway of histamine metabolism in mammals ?
-
 ?
2.1.1.8 additional information Felis catus major pathway of histamine metabolism in mammals ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Cavia porcellus
-
-
-
2.1.1.8 Felis catus
-
-
-
2.1.1.8 Mus musculus
-
-
-
2.1.1.8 Oryctolagus cuniculus
-
-
-
2.1.1.8 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.8
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 abdomen abdominal skin Cavia porcellus
-
2.1.1.8 abdomen abdominal skin Mus musculus
-
2.1.1.8 abdomen abdominal skin Rattus norvegicus
-
2.1.1.8 abdomen abdominal skin Oryctolagus cuniculus
-
2.1.1.8 abdomen abdominal skin Felis catus
-
2.1.1.8 adrenal gland
-
 Cavia porcellus
-
2.1.1.8 adrenal gland
-
 Oryctolagus cuniculus
-
2.1.1.8 adrenal gland
-
 Felis catus
-
2.1.1.8 brain
-
 Cavia porcellus
-
2.1.1.8 brain
-
 Mus musculus
-
2.1.1.8 brain
-
 Rattus norvegicus
-
2.1.1.8 brain
-
 Oryctolagus cuniculus
-
2.1.1.8 brain
-
 Felis catus
-
2.1.1.8 heart
-
 Cavia porcellus
-
2.1.1.8 heart
-
 Mus musculus
-
2.1.1.8 heart
-
 Rattus norvegicus
-
2.1.1.8 heart
-
 Oryctolagus cuniculus
-
2.1.1.8 heart
-
 Felis catus
-
2.1.1.8 ileum
-
 Cavia porcellus
-
2.1.1.8 ileum
-
 Rattus norvegicus
-
2.1.1.8 ileum
-
 Oryctolagus cuniculus
-
2.1.1.8 ileum
-
 Felis catus
-
2.1.1.8 kidney
-
 Cavia porcellus
-
2.1.1.8 kidney
-
 Mus musculus
-
2.1.1.8 kidney
-
 Rattus norvegicus
-
2.1.1.8 kidney
-
 Oryctolagus cuniculus
-
2.1.1.8 kidney
-
 Felis catus
-
2.1.1.8 liver
-
 Cavia porcellus
-
2.1.1.8 liver
-
 Mus musculus
-
2.1.1.8 liver
-
 Oryctolagus cuniculus
-
2.1.1.8 liver
-
 Felis catus
-
2.1.1.8 liver not in rat Rattus norvegicus
-
2.1.1.8 lung
-
 Cavia porcellus
-
2.1.1.8 lung
-
 Mus musculus
-
2.1.1.8 lung
-
 Oryctolagus cuniculus
-
2.1.1.8 lung
-
 Felis catus
-
2.1.1.8 lung not in rat Rattus norvegicus
-
2.1.1.8 pancreas
-
 Felis catus
-
2.1.1.8 sciatic nerve
-
 Cavia porcellus
-
2.1.1.8 sciatic nerve
-
 Oryctolagus cuniculus
-
2.1.1.8 sciatic nerve
-
 Felis catus
-
2.1.1.8 spleen
-
 Cavia porcellus
-
2.1.1.8 spleen
-
 Mus musculus
-
2.1.1.8 spleen
-
 Oryctolagus cuniculus
-
2.1.1.8 spleen
-
 Felis catus
-
2.1.1.8 spleen not in rat Rattus norvegicus
-
2.1.1.8 stomach
-
 Cavia porcellus
-
2.1.1.8 stomach
-
 Mus musculus
-
2.1.1.8 stomach
-
 Oryctolagus cuniculus
-
2.1.1.8 stomach
-
 Felis catus
-
2.1.1.8 thigh muscle
-
 Cavia porcellus
-
2.1.1.8 thigh muscle
-
 Mus musculus
-
2.1.1.8 thigh muscle
-
 Rattus norvegicus
-
2.1.1.8 thigh muscle
-
 Oryctolagus cuniculus
-
2.1.1.8 thigh muscle
-
 Felis catus
-
2.1.1.8 trachea
-
 Cavia porcellus
-
2.1.1.8 trachea
-
 Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.8 25.4
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 additional information major pathway of histamine metabolism in mammals Cavia porcellus ?
-
 ?
2.1.1.8 additional information major pathway of histamine metabolism in mammals Mus musculus ?
-
 ?
2.1.1.8 additional information major pathway of histamine metabolism in mammals Rattus norvegicus ?
-
 ?
2.1.1.8 additional information major pathway of histamine metabolism in mammals Oryctolagus cuniculus ?
-
 ?
2.1.1.8 additional information major pathway of histamine metabolism in mammals Felis catus ?
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Mus musculus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Felis catus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.8 37
-
 assay at Cavia porcellus
2.1.1.8 37
-
 assay at Mus musculus
2.1.1.8 37
-
 assay at Rattus norvegicus
2.1.1.8 37
-
 assay at Oryctolagus cuniculus
2.1.1.8 37
-
 assay at Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 7.2 7.4
-
 Cavia porcellus
2.1.1.8 7.2 7.4
-
 Mus musculus