Literature summary extracted from

Veser, J.
Kinetics and inhibition studies of catechol O-methyltransferase from the yeast Candida tropicalis (1987), J. Bacteriol., 169, 3696-3700.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.6	2-Iodosobenzoic acid	-	Candida tropicalis
2.1.1.6	4-nitrocatechol	-	Candida tropicalis
2.1.1.6	Ca2+	-	Candida tropicalis
2.1.1.6	catechol	-	Candida tropicalis
2.1.1.6	gallic acid	-	Candida tropicalis
2.1.1.6	Gallic acid methylester	-	Candida tropicalis
2.1.1.6	iodoacetamide	slight	Candida tropicalis
2.1.1.6	L-ascorbic acid	-	Candida tropicalis
2.1.1.6	L-Dopa	-	Candida tropicalis
2.1.1.6	Mg2+	required for activity	Candida tropicalis
2.1.1.6	p-chloromercuribenzoate	-	Candida tropicalis
2.1.1.6	purpurogallin	-	Candida tropicalis
2.1.1.6	pyrogallol	-	Candida tropicalis
2.1.1.6	S-adenosyl-L-homocysteine	-	Candida tropicalis
2.1.1.6	tropolone	-	Candida tropicalis

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.1.1.6	additional information	-	additional information	-	Candida tropicalis
2.1.1.6	0.0031	-	S-adenosyl-L-methionine	cosubstrate esculetin	Candida tropicalis
2.1.1.6	0.0062	-	esculetin	-	Candida tropicalis
2.1.1.6	0.04	-	S-adenosyl-L-methionine	cosubstrate esculetin	Candida tropicalis

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.1.1.6	Mg2+	required	Candida tropicalis
2.1.1.6	Mn2+	-	Candida tropicalis
2.1.1.6	Zn2+	can substitute for Mg2+	Candida tropicalis

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.6	Candida tropicalis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.6	esculetin + S-adenosyl-L-methionine	-	Candida tropicalis	S-adenosyl-L-homocysteine + ?	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.1.1.6	0.007	-	S-adenosyl-L-homocysteine	cosubstrate S-adenosyl-L-methionine	Candida tropicalis
2.1.1.6	0.07	-	purpurogallin	-	Candida tropicalis

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Release 2023.1 (January 2023)