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Literature summary extracted from

  • Borchardt, R.T.
    Catechol O-methyltransferase (1981), Methods Enzymol., 77, 267-272.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 Ca2+
-
 Rattus norvegicus
2.1.1.6 iodoacetic acid
-
 Rattus norvegicus
2.1.1.6 Mg2+ inhibition above 2 mM; required for activity Rattus norvegicus
2.1.1.6 N-ethylmaleimide
-
 Rattus norvegicus
2.1.1.6 p-chloromercuribenzoate
-
 Rattus norvegicus
2.1.1.6 S-adenosyl-L-homocysteine
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.6 Mg2+ required Rattus norvegicus
2.1.1.6 Mg2+ inhibition above 2 mM Rattus norvegicus
2.1.1.6 Mg2+ below 2 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.6 23000
-
 x * 23000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.6 additional information Rattus norvegicus primary role in extraneuronal inactivation of endogenous catecholamines and in the further metabolism of oxidized catecholamine metabolites ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.6
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.6 additional information
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.1.1.6 -4°C, stable for several weeks Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 additional information not: monophenols Rattus norvegicus ?
-
 ?
2.1.1.6 additional information strict requirement for S-adenosyl-L-methionine as methyl donor and a catechol as acceptor substrate Rattus norvegicus ?
-
 ?
2.1.1.6 additional information primary role in extraneuronal inactivation of endogenous catecholamines and in the further metabolism of oxidized catecholamine metabolites Rattus norvegicus ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.6 ? x * 23000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.6 7.3 8.2
-
 Rattus norvegicus