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Literature summary extracted from

  • Huh, M.M.O.; Friedhoff, A.J.
    Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization (1979), J. Biol. Chem., 254, 299-308.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 soluble
-
 Homo sapiens
-
-
2.1.1.6 soluble
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.6 24000
-
 COMT I, gel filtration, sedimentation data Rattus norvegicus
2.1.1.6 47500
-
 COMT II, gel filtration, sedimentation data Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.6 additional information Homo sapiens physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
 ?
2.1.1.6 additional information Rattus norvegicus physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
 ?
2.1.1.6 additional information Oryctolagus cuniculus physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol Homo sapiens
-
 ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol Rattus norvegicus
-
 ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol Oryctolagus cuniculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
 2 forms
-
2.1.1.6 Oryctolagus cuniculus
-
-
-
2.1.1.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.6
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 brain
-
 Homo sapiens
-
2.1.1.6 brain
-
 Rattus norvegicus
-
2.1.1.6 heart
-
 Rattus norvegicus
-
2.1.1.6 kidney
-
 Rattus norvegicus
-
2.1.1.6 liver
-
 Homo sapiens
-
2.1.1.6 liver
-
 Rattus norvegicus
-
2.1.1.6 liver
-
 Oryctolagus cuniculus
-
2.1.1.6 lung
-
 Homo sapiens
-
2.1.1.6 lung
-
 Rattus norvegicus
-
2.1.1.6 lung
-
 Oryctolagus cuniculus
-
2.1.1.6 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.6 additional information
-
-
 Homo sapiens
2.1.1.6 additional information
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.1.1.6 -20°C, or -60°C, 50 mM Tris-HCl, pH 7.5, 20 mM 2-mercaptoethanol, 20% v/v glycerol, 60-80% of activity retained after 6 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Homo sapiens ?
-
 ?
2.1.1.6 additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Rattus norvegicus ?
-
 ?
2.1.1.6 additional information physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs Oryctolagus cuniculus ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol
-
 Homo sapiens ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol
-
 Rattus norvegicus ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + a catechol
-
 Oryctolagus cuniculus ?
-
 ?