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Literature summary extracted from

  • Chave, K.J.; Snell, K.; Sanders, P.G.
    Isolation and characterization of human genomic sequences encoding cytosolic serine hydroxymethyltransferase (1997), Biochem. Soc. Trans., 25, 53S.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.2.1
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate Homo sapiens main glycine source for purine biosynthetic pathway in ureide biogenesis glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?
2.1.2.1 L-serine + tetrahydrofolate main glycine source for purine biosynthetic pathway in ureide biogenesis Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.1 pyridoxal 5'-phosphate one mol/subunit bound to the epsilon-amino group of lysine Homo sapiens
2.1.2.1 tetrahydrofolate
-
 Homo sapiens