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Literature summary extracted from

  • Strong, W.B.; Tendler, S.J.; Seither, R.L.; Goldman, I.D.; Schirch, V.
    Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells (1990), J. Biol. Chem., 265, 12149-12155.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.1 L-serine
-
Mus musculus
2.1.2.1 tetrahydrofolate derivatives
-
Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.1 additional information
-
additional information
-
Mus musculus
2.1.2.1 0.15 0.9 L-serine
-
Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytoplasm
-
Mus musculus 5737
-
2.1.2.1 mitochondrion
-
Mus musculus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.2.1 56000
-
4 * 56000, SDS-PAGE Mus musculus
2.1.2.1 215000
-
HPLC gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate Mus musculus main glycine source for purine biosynthetic pathway in ureide biogenesis glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
2.1.2.1 L-serine + tetrahydrofolate Mus musculus key enzyme of serine pathway for assimilation of C1-compounds glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.2.1
-
Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.2.1 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine mechanism Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 L-1210 cell transformed cells Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.2.1 9.7
-
-
Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
Mus musculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
2.1.2.1 L-serine + tetrahydrofolate main glycine source for purine biosynthetic pathway in ureide biogenesis Mus musculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
?
2.1.2.1 L-serine + tetrahydrofolate key enzyme of serine pathway for assimilation of C1-compounds Mus musculus glycine + 5,10-methylenetetrahydrofolate + H2O
-
?

Subunits

EC Number Subunits Comment Organism
2.1.2.1 homotetramer 4 * 56000, SDS-PAGE Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.2.1 additional information
-
additional information
-
Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.1 additional information
-
additional information
-
Mus musculus