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Literature summary extracted from

  • Rudiger, H.
    On the cation sensibility of the vitamin B12-dependent methionine synthetase (5-methyltetrahydrofolate-homocysteine-methyltransferase from Escherichia coli) (1973), FEBS Lett., 35, 295-298.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.13 K+ at 67 mM 1.4 fold activity Escherichia coli
2.1.1.13 Li+ at 67 mM, 1.3fold activity Escherichia coli
2.1.1.13 Na+ at 67 mM 1.5 fold activity Escherichia coli
2.1.1.13 NH4+ at 67 mM 1.5 fold activity Escherichia coli
2.1.1.13 S-adenosylmethionine at about 0.0001 mM Escherichia coli
2.1.1.13 TrisHCl at 67 mM 1.2 fold activity Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.13 Mg2+ activates Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.13 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.13 N5-methyltetrahydrofolate + L-homocysteine
-
 Escherichia coli tetrahydrofolate + L-methionine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.13 vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Escherichia coli