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Literature summary extracted from

  • Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
    Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli (1964), Biochem. J., 92, 497-504.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.14 Mn2+ above 1 mM Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.13 Mg2+ required Escherichia coli
2.1.1.14 Mg2+ required Escherichia coli
2.1.1.14 Mn2+ below 1 mM more effective than Mg2+, above 1 mM inhibitory Escherichia coli
2.1.1.14 phosphate
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.13 Escherichia coli
-
 B
-
2.1.1.13 Escherichia coli B / ATCC 11303
-
 B
-
2.1.1.14 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.13 additional information S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent Escherichia coli ?
-
 ?
2.1.1.13 additional information S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent Escherichia coli B / ATCC 11303 ?
-
 ?
2.1.1.13 N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroylmonoglutamate + L-methionine
-
 ?
2.1.1.13 N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
 Escherichia coli B / ATCC 11303 tetrahydropteroylmonoglutamate + L-methionine
-
 ?
2.1.1.13 N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroyltriglutamate + L-methionine
-
 ?
2.1.1.13 N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
 Escherichia coli B / ATCC 11303 tetrahydropteroyltriglutamate + L-methionine
-
 ?
2.1.1.14 5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
 Escherichia coli tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
 ?
2.1.1.14 5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine
-
 Escherichia coli B / ATCC 11303 tetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-methionine
-
 ?
2.1.1.14 additional information monoglutamate analog not used Escherichia coli ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Escherichia coli B / ATCC 11303 ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.14 8.1
-
-
 Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.14 6 8.7 pH 6.0: about 70% of maximum activity, pH 8.7: about 90% of maximum activity Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.13 ATP required Escherichia coli
2.1.1.13 additional information enzyme requires another protein fraction, ATP, Mg2+, FAD and a NADH-generating system Escherichia coli
2.1.1.13 vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Escherichia coli
2.1.1.14 additional information vitamin-B12 independent enzyme Escherichia coli