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Literature summary extracted from

  • Bui, V.P.; Vidar Hansen, T.; Stenstrom, Y.; Hudlicky, T.; Ribbons, D.W.
    A study of substrate specificity of toluene dioxygenase in processing aromatic compounds containing benzylic and/or remote chiral centers (2001), New J. Chem., 25, 116-124.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.14.12.11 synthesis screening of substituted arenes containing remote chiral centers as substrates, enantiomers are indiscriminately processed to diastereomeric pairs. Some of these new metabolites are useful as synthons for morphine synthesis Pseudomonas putida

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.11 Pseudomonas putida
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.11 (+/-)-trans-2-phenyl-1-cyclohexanol + NADH + O2
-
 Pseudomonas putida 3-(2-hydroxycyclohexanyl)-3,5-cyclohexadiene-1,2-diol + ?
-
 ?
1.14.12.11 (1R,2S)-(-)-trans-2-phenyl-1-cyclohexanol + NADH + O2
-
 Pseudomonas putida 3-(2-hydroxycyclohexanyl)-3,5-cyclohexadiene-1,2-diol + ?
-
 ?
1.14.12.11 (R)-1-phenyl-1-ethanol + NADH + O2
-
 Pseudomonas putida 3-[1(R)-hydroxyethyl]cyclohexa-3,5-diene-1(S),2(R)-diol + ?
-
 ?
1.14.12.11 (R)-2-phenylcyclohexanone + NADH + O2
-
 Pseudomonas putida (4S,4aR,9aR)-4,6,7,8,9,9a-hexahydro-4aH-dibenzofuran-4,5a-diol + ?
-
 ?
1.14.12.11 (S)-1-phenyl-1-ethanol + O2 + NADH + O2
-
 Pseudomonas putida 3-[1(S)-hydroxyethyl]cyclohexa-3,5-diene-1(S),2(R)-diol + ?
-
 ?
1.14.12.11 (S)-2-phenylcyclohexanone + NADH + O2
-
 Pseudomonas putida (1S,5'S,6'R)-5',6'-dihydroxybicyclohexyl-1',3'-diene-2-one + ?
-
 ?
1.14.12.11 1-phenylcyclohexene + NADH + O2
-
 Pseudomonas putida (1S,2R)-3-(1-cyclohexenyl)-3,5-cyclohexadiene-1,2-diol + ?
-
 ?
1.14.12.11 3-phenylcyclohexene + NADH + O2
-
 Pseudomonas putida (1S,2R)-3-(cyclohexenyl)-3,5-cyclohexadiene-1,2-diol + ?
-
 ?
1.14.12.11 diphenylmethane + NADH + O2
-
 Pseudomonas putida (1S,2R)-3-benzylcyclohexa-3,5-diene-1,2-diol + ?
-
 ?
1.14.12.11 additional information screening of substituted arenes containing remote chiral centers as substrates, enantiomers are indiscriminately processed to diastereomeric pairs Pseudomonas putida ?
-
 ?
1.14.12.11 phenylcyclohexane + NADH + O2
-
 Pseudomonas putida (1S,2R)-3-(1-cyclohexyl)-3,5-cyclohexadiene-1,2-diol + ?
-
 ?
1.14.12.11 toluene + NADH + O2
-
 Pseudomonas putida (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.11 NADH
-
 Pseudomonas putida