Literature summary extracted from

Milla, P.; Lenhart, A.; Grosa, G.; Viola, F.; Weihofen, W.A.; Schulz, G.E.; Balliano, G.
Thiol-modifying inhibitors for understanding squalene cyclase function (2002), Eur. J. Biochem., 269, 2108-2116.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
5.4.99.17	-	Alicyclobacillus acidocaldarius

Protein Variants

EC Number	Protein Variants	Comment	Organism
5.4.99.17	additional information	modification of critically located Cys residues	Alicyclobacillus acidocaldarius

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.4.99.17	3-carboxy-4-nitrophenyl-dithio-1,1',2-trisnorsqualene	covalently modifies C435	Alicyclobacillus acidocaldarius
5.4.99.17	additional information	effect of thiol-modifying inhibitors on mutant enzymes	Alicyclobacillus acidocaldarius
5.4.99.17	squalene-maleimide	time-dependent inhibitor	Alicyclobacillus acidocaldarius

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
5.4.99.17	additional information	-	additional information	Km for wild type and mutant enzymes	Alicyclobacillus acidocaldarius

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.4.99.17	Alicyclobacillus acidocaldarius	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.4.99.17	squalene	-	Alicyclobacillus acidocaldarius	hop-22(29)-ene	-	?

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
5.4.99.17	additional information	-	additional information	wild type and mutant enzymes	Alicyclobacillus acidocaldarius

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Release 2023.1 (January 2023)