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Literature summary extracted from
- Squalene-hopene cyclase: catalytic mechanism and substrate recognition (2002), Chem. Commun. (Camb.), 2000, 291-301.
No PubMed abstract available
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.99.17 | - |
Alicyclobacillus acidocaldarius |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.4.99.17 | additional information | overview | Alicyclobacillus acidocaldarius |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.17 | additional information | sulfur-substituted oxidosqualene analogues serve as inhibitors | Alicyclobacillus acidocaldarius | |
| 5.4.99.17 | N,N-dimethyldodecylamine N-oxide | forms a complex with the enzyme | Alicyclobacillus acidocaldarius |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.99.17 | additional information | - |
additional information | Km for wild type and mutant enzymes | Alicyclobacillus acidocaldarius |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.17 | Alicyclobacillus acidocaldarius | - |
- |
- |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.4.99.17 | additional information | - |
specific activities for wild type and mutant enzymes | Alicyclobacillus acidocaldarius |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.17 | additional information | overview of cyclization products of wild type and mutant enzymes | Alicyclobacillus acidocaldarius | ? | - |
? | |
| 5.4.99.17 | squalene | - |
Alicyclobacillus acidocaldarius | hop-22(29)-ene | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.4.99.17 | additional information | - |
wild type and mutant enzymes | Alicyclobacillus acidocaldarius |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.99.17 | additional information | - |
additional information | wild type and mutant enzymes | Alicyclobacillus acidocaldarius |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.4.99.17 | additional information | - |
additional information | Ki for sulfur-substituted oxidosqualene analogues | Alicyclobacillus acidocaldarius |
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Release 2023.1 (January 2023)
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