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Literature summary extracted from

  • Banerjee, U.C.
    Characterization of soluble rifamycin oxidase from Curvularia lunata var. aeria (1993), Lett. Appl. Microbiol., 17, 1-3.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.10.3.6 medicine rifamycin S is used for the production of the antibiotic rifampicin for treatment of leprosy and tuberculosis Curvularia lunata

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.3.6 Ag+ 60% inhibition at 20 mM Curvularia lunata
1.10.3.6 Co2+ slight inhibition Curvularia lunata
1.10.3.6 Cu2+ slight inhibition Curvularia lunata
1.10.3.6 Fe2+ 90% inhibition at 20 mM Curvularia lunata
1.10.3.6 Hg2+ complete inhibition at 20 mM Curvularia lunata

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.3.6 0.67 0.81 Rifamycin B
-
 Curvularia lunata

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.3.6 extracellular
-
 Curvularia lunata
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.6 additional information not affected by other metal ions than Fe2+, Hg2+, Ag+, Cu2+, Co2+ or EDTA Curvularia lunata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.3.6 rifamycin B + O2 Curvularia lunata
-
 rifamycin O + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.6 Curvularia lunata
-
 var. aeria
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.3.6 partially, gel filtration Curvularia lunata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.6 rifamycin B + O2
-
 Curvularia lunata rifamycin O + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.10.3.6 50
-
-
 Curvularia lunata

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.10.3.6 30
-
 half life of 9 days, after 7 days nearly 100% of activity is retained Curvularia lunata
1.10.3.6 40
-
 half life of 100 min, activity directly declined Curvularia lunata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.10.3.6 6.5
-
-
 Curvularia lunata