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Literature summary extracted from

  • May, S.W.; Mueller, P.W.; Oldham, C.D.; Williamson, C.K.; Sowell, A.L.
    Protocatechuate 3,4-dioxygenase: comparative study of inhibition and active-site interactions of pyridine N-oxides (1983), Biochemistry, 22, 5331-5340.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.3 2-Hydroxyisonicotinic acid N-oxide
-
 Pseudomonas sp.
1.13.11.3 2-Hydroxypyridine N-oxide
-
 Pseudomonas sp.
1.13.11.3 isonicotinic acid N-oxide
-
 Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.3 Pseudomonas sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.3 3,4-dihydroxybenzoate + O2
-
 Pseudomonas sp. 3-carboxy-cis,cis-muconate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.3 0.0068
-
 2-Hydroxyisonicotinic acid N-oxide apparent Ki, irreversible binding Pseudomonas sp.
1.13.11.3 1.3
-
 isonicotinic acid N-oxide
-
 Pseudomonas sp.
1.13.11.3 3.9
-
 2-Hydroxypyridine N-oxide apparent Ki, inhibition is not freely reversible Pseudomonas sp.