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Literature summary extracted from

  • Savage, N.; Levy, P.R.
    The purification and some properties of 3-hydroxyanthranilate oxygenase from baboon liver (1975), Int. J. Biochem., 6, 459-466.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.6 p-chloromercuriphenyl sulfonic acid
-
 Papio ursinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.6 0.01
-
 4-Propyl-3-hydroxyanthranilic acid
-
 Papio ursinus
1.13.11.6 0.011
-
 4-ethyl-3-hydroxyanthranilic acid
-
 Papio ursinus
1.13.11.6 0.037
-
 4-methyl-3-hydroxyanthranilic acid
-
 Papio ursinus
1.13.11.6 0.105
-
 3-hydroxyanthranilic acid
-
 Papio ursinus
1.13.11.6 0.615
-
 O2
-
 Papio ursinus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.6 Fe2+ requirement Papio ursinus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.6 35000 40000 gel filtration, SDS-PAGE Papio ursinus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2 Papio ursinus enzyme occurs in the metabolic pathway of the conversion of tryptophan to nicotinic acid 2-amino-3-carboxymuconate semialdehyde
-
 ?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
1.13.11.6 additional information enzyme is not stable, when stored frozen in 20 mM Tris-maleate buffer, 1 mM dithiothreitol and 1 mM FeSO4 at pH 6.5 Papio ursinus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.6 Papio ursinus
-
 baboon
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.6
-
 Papio ursinus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.6 liver
-
 Papio ursinus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.6 7.8
-
-
 Papio ursinus

Storage Stability

EC Number Storage Stability Organism
1.13.11.6 4°C, overnight, 75% loss of activity Papio ursinus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2
-
 Papio ursinus 2-amino-3-carboxymuconate semialdehyde
-
 ?
1.13.11.6 3-hydroxyanthranilate + O2 enzyme occurs in the metabolic pathway of the conversion of tryptophan to nicotinic acid Papio ursinus 2-amino-3-carboxymuconate semialdehyde
-
 ?
1.13.11.6 4-ethyl-3-hydroxyanthranilate + O2
-
 Papio ursinus 2-amino-3-carboxy-4-ethylmuconate semialdehyde
-
 ?
1.13.11.6 4-methyl-3-hydroxyanthranilate + O2
-
 Papio ursinus 2-amino-3-carboxy-4-methylmuconate semialdehyde
-
 ?
1.13.11.6 4-propyl-3-hydroxyanthranilic acid + O2
-
 Papio ursinus 2-amino-3-carboxy-4-propylmuconate semialdehyde
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.6 monomer 1 * 35000-40000, SDS-PAGE Papio ursinus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.6 37
-
 assay at Papio ursinus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.6 7.4 7.6
-
 Papio ursinus