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Literature summary extracted from

  • Foster, A.C.; White, R.J.; Schwarcz, R.
    Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro (1986), J. Neurochem., 47, 23-30.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.6 additional information not at a concentration of 0.5 mM: L-tryptophan, quinolinic acid, kynurenic acid, nicotinic acid mononucleotide, picolinic acid, phthalic acid, glutaric acid, L-aspartic acid, L-glutamic acid, N-methyl-D-aspartic acid, kainic acid Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.6 0.003 0.0036 3-hydroxyanthranilic acid
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.6 soluble
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.6 Fe2+ requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2 Rattus norvegicus in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ 2-amino-3-carboxymuconate semialdehyde
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.6 brain regional distribution Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
1.13.11.6 -80°C, as homogenate stable for 2 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.6 3-hydroxyanthranilate + O2 high selectivity for substrate Rattus norvegicus 2-amino-3-carboxymuconate semialdehyde reacts spontaneously to quinolinic acid ?
1.13.11.6 3-hydroxyanthranilate + O2 in mammalian peripheral organs the enzyme constitutes a link in the catabolic pathway of tryptophan to NAD+ Rattus norvegicus 2-amino-3-carboxymuconate semialdehyde
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.6 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.6 6
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.13.11.6 4.5 7 at pH 4.5: about 70% of activity maximum, at pH 7.0: about 50% of activity maximum Rattus norvegicus