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Literature summary extracted from

  • Hutton, J.J.; Tappel, A.L.; Udenfried, S.
    Cofactor and substrate requirements of collagen proline hydroxylase (1967), Arch. Biochem. Biophys., 118, 231-240.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 1,10-phenanthroline 91% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 2,2'-dipyridyl
-
 Gallus gallus
1.14.11.2 2,2'-dipyridyl 87% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 antimycin A 18% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 Cupferron 28% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 diethyldithiocarbamate 10% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 EDTA
-
 Gallus gallus
1.14.11.2 EDTA 64% inhibition at 0.02 mM Rattus norvegicus
1.14.11.2 gelatin commercial, inhibitor Cavia porcellus
1.14.11.2 gelatin commercial, inhibitor Gallus gallus
1.14.11.2 gelatin commercial, inhibitor Rattus norvegicus
1.14.11.2 Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Cavia porcellus
1.14.11.2 Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Gallus gallus
1.14.11.2 Ketomalonate 100% inhibition at 1 mM, acts by chelating ferrous ion rather than by competing with alpha-ketoglutarate Rattus norvegicus
1.14.11.2 malonate 19% inhibition at 1 mM Cavia porcellus
1.14.11.2 malonate 19% inhibition at 1 mM Gallus gallus
1.14.11.2 malonate 19% inhibition at 1 mM Rattus norvegicus
1.14.11.2 oxalate 34% inhibition at 1 mM Cavia porcellus
1.14.11.2 oxalate 34% inhibition at 1 mM Gallus gallus
1.14.11.2 oxalate 34% inhibition at 1 mM Rattus norvegicus
1.14.11.2 propyl gallate 100% inhibition at 2 mM Cavia porcellus
1.14.11.2 propyl gallate 100% inhibition at 2 mM Gallus gallus
1.14.11.2 propyl gallate 100% inhibition at 2 mM Rattus norvegicus
1.14.11.2 succinate 51% inhibition at 1 mM Cavia porcellus
1.14.11.2 succinate 51% inhibition at 1 mM Gallus gallus
1.14.11.2 succinate 51% inhibition at 1 mM Rattus norvegicus
1.14.11.2 trifluorothienylbutanedione 48% inhibition at 0.05 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.2 0.03
-
 O2
-
 Gallus gallus
1.14.11.2 0.03
-
 O2
-
 Rattus norvegicus
1.14.11.2 0.03
-
 peptidyl L-proline
-
 Cavia porcellus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+ no compound can replace Fe2+, Km: 0.03 mM Gallus gallus
1.14.11.2 Fe2+ no compound can replace Fe2+, Km: 0.03 mM Cavia porcellus
1.14.11.2 Fe2+ no compound can replace Fe2+, Km: 0.03 mM Rattus norvegicus
1.14.11.2 Mg2+ 3% relative activity with respect to Fe2+ Gallus gallus
1.14.11.2 Mn2+ 10% relative activity with respect to Fe2+ Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Cavia porcellus
-
-
-
1.14.11.2 Gallus gallus
-
-
-
1.14.11.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 embryo
-
 Gallus gallus
-
1.14.11.2 skin
-
 Gallus gallus
-
1.14.11.2 skin fetus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 peptidyl L-proline + 2-oxoglutarate + O2
-
 Cavia porcellus peptidyl-trans-4-hydroxy-L-proline + succinate + CO2
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.2 30
-
-
 Gallus gallus
1.14.11.2 30
-
-
 Cavia porcellus
1.14.11.2 30
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.2 2-oxoglutarate no compound can replace alpha-ketoglutarate Gallus gallus
1.14.11.2 2-oxoglutarate no compound can replace alpha-ketoglutarate Cavia porcellus
1.14.11.2 2-oxoglutarate no compound can replace alpha-ketoglutarate Rattus norvegicus
1.14.11.2 ascorbate requirement Gallus gallus
1.14.11.2 ascorbate requirement Cavia porcellus
1.14.11.2 ascorbate requirement Rattus norvegicus
1.14.11.2 ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Gallus gallus
1.14.11.2 ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Cavia porcellus
1.14.11.2 ascorbate Km: 0.2-1 mM, dependent on the concentrations of alpha-ketoglutarate and Fe2+, reduced pteridines can partially replace ascorbate Rattus norvegicus
1.14.11.2 D-isoascorbate can replace ascorbate Gallus gallus
1.14.11.2 D-isoascorbate can replace ascorbate Cavia porcellus
1.14.11.2 D-isoascorbate can replace ascorbate Rattus norvegicus