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Literature summary extracted from

  • Hussain, M.Z.; Ghani, Q.P.; Hunt, T.K.
    Inhibition of prolyl hydroxylase by poly(ADP-ribose) and phosphoribosyl-AMP. Possible role of ADP-ribosylation in intracellular prolyl hydroxylase regulation (1989), J. Biol. Chem., 264, 7850-7855.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.2 Lactate stimulates, the activation of the enzyme in lactate-treated fibroblasts is correlated with a reduction in the total ADP-ribosylation Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 ADP-ribose weak inhibitor Gallus gallus
1.14.11.2 additional information the synthesis and degradation of ADP-ribose moieties may possibly regulate prolyl hydroxylase activity in vivo Gallus gallus
1.14.11.2 phosphoribosyl adenosine monophosphate 46% inhibition at 25 nM, 87% inhibition at 50 nM Gallus gallus
1.14.11.2 Poly(ADP-ribose) near complete inhibition at 6 nM, the effect is noncompetitive with respect to the binding of the cofactors ascorbate and alpha-ketoglutarate or of the substrate Gallus gallus
1.14.11.2 Ribosyl-ribosyl-adenine 43% inhibition at 25 nM, 85% inhibition at 50 nM Gallus gallus
1.14.11.2 Ribosyl-ribosyl-hypoxanthine 40% inhibition at 25 nM, 86% inhibition at 50 nM Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.2 using ammonium sulfate precipitation, calcium phosphate batch fractionations and anion exchange chromatography on DEAE-agarose followed by gel filtration on agarose Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 embryo
-
 Gallus gallus
-

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.2 2-oxoglutarate
-
 Gallus gallus
1.14.11.2 ascorbate
-
 Gallus gallus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.11.2 0.0000015
-
 Poly(ADP-ribose)
-
 Gallus gallus
1.14.11.2 0.0000162
-
 phosphoribosyl adenosine monophosphate
-
 Gallus gallus
1.14.11.2 0.0000162
-
 Ribosyl-ribosyl-adenine
-
 Gallus gallus