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Literature summary extracted from
- Inhibition of lysyl hydroxylase by catechol analogs (1977), Biochim. Biophys. Acta, 481, 63-70.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.4 | Adrenochrome | slight | Gallus gallus |  |
| 1.14.11.4 | catechol | - |
Gallus gallus | |
| 1.14.11.4 | DL-Serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide | most potent | Gallus gallus | |
| 1.14.11.4 | dopamine | - |
Gallus gallus | |
| 1.14.11.4 | ephedrine | slight | Gallus gallus | |
| 1.14.11.4 | epinephrine | - |
Gallus gallus | |
| 1.14.11.4 | norepinephrine | - |
Gallus gallus | |
| 1.14.11.4 | phenylalanine | slight | Gallus gallus | |
| 1.14.11.4 | Phenylephedrine | slight | Gallus gallus | |
| 1.14.11.4 | pyrogallol | most potent | Gallus gallus | |
| 1.14.11.4 | tyrosine | slight | Gallus gallus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.4 | Fe2+ | - |
Gallus gallus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | Gallus gallus | influence the integrity and stability of collagen | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.4 | Gallus gallus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.14.11.4 | side-chain modification | hydroxylation of lysyl residue in -X-Lys-Gly | Gallus gallus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.11.4 | embryo | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.4 | collagen + 2-oxoglutarate + O2 | influence the integrity and stability of collagen | Gallus gallus | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.4 | 0.015 | - |
catechol | - |
Gallus gallus | |
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