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Literature summary extracted from

  • Xun, L.; Topp, E.; Orser, C.S.
    Diverse substrate range of a Flavobacterium pentachlorophenol hydroxylase and reaction stoichiometries (1992), J. Bacteriol., 174, 2898-2902.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.14.13.50 environmental protection development of biological methods for the decontamination of halophenol-polluted sites Flavobacterium sp.

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.50 Flavobacterium sp.
-
 strain ATCC 39723
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.50 2,3,4-trichlorophenol + NADPH + O2 low activity Flavobacterium sp. ?
-
 ?
1.14.13.50 2,3,5,6-tetrachlorophenol + NADPH + O2
-
 Flavobacterium sp. 2,3,5,6-tetrachloro-p-hydroquinone + NADP+
-
 ?
1.14.13.50 2,3,6-trichlorophenol + NADPH + O2
-
 Flavobacterium sp. 2,3,6-trichloro-p-hydroquinone + NADP+ + H2O
-
 ?
1.14.13.50 2,3-dichlorophenol + NADPH + O2 low activity Flavobacterium sp. ?
-
 ?
1.14.13.50 2,4,6-tribromophenol + NADPH + O2 low activity Flavobacterium sp. 2,6-dibromo-p-hydroquinone + Br- + NADP+ + H2O
-
 ?
1.14.13.50 2,4,6-trichlorophenol + NADPH + O2 low activity Flavobacterium sp. 2,6-dichloro-p-hydroquinone + Cl- + NADP+ + H2O
-
 ?
1.14.13.50 2,6-dibromo-4-nitrophenol + NADPH + O2 low activity Flavobacterium sp. 2,6-dibromo-p-hydroquinone + NO2- + NADP+ + H2O
-
 ?
1.14.13.50 2,6-dibromophenol + NADPH + O2
-
 Flavobacterium sp. 2,6-dibromo-p-hydroquinone + NADP+ + H2O
-
 ?
1.14.13.50 2,6-dichlorophenol + NADPH + O2
-
 Flavobacterium sp. 2,6-dichloro-p-hydroquinone + NADP+ + H2O
-
 ?
1.14.13.50 3,5-dibromo-4-hydroxybenzonitrile + 2 NADPH + 2 H+ + O2
-
 Flavobacterium sp. 2,6-dibromo-p-hydroquinone + CN- + 2 NADP+ + H2O
-
 ?
1.14.13.50 3,5-diiodo-4-hydroxybenzonitrile + NADPH + O2
-
 Flavobacterium sp. ?
-
 ?
1.14.13.50 4-amino-2,6-dichlorophenol + NADPH + O2 low activity Flavobacterium sp. 2,6-dichloro-p-hydroquinone + NADP+ + NH2OH
-
 ?
1.14.13.50 additional information overview: enzyme catalyzes a primary attack on a broad range of substituted phenols, hydroxylating the para position and removing halogen, nitro, amino and cyano groups to produce halide, nitrite, hydroxylamine and cyanide respectively Flavobacterium sp. ?
-
 ?
1.14.13.50 additional information no activity with 3,4,5-trichlorophenol, 3,5-dichlorophenol Flavobacterium sp. ?
-
 ?
1.14.13.50 pentachlorophenol + NADPH + H+ + O2
-
 Flavobacterium sp. 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
-
 ?
1.14.13.50 pentafluorophenol + NADPH + O2 low activity Flavobacterium sp. ?
-
 ?
1.14.13.50 triiodophenol + NADPH + O2
-
 Flavobacterium sp. diiodohydroquinone + iodide + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.50 NADPH elimination of 1 mol of a halogen, nitro, or cyano group requires 2 mol of NADPH, 1 mol of NADPH is required to remove 1 mol of an amino group or hydrogen Flavobacterium sp.