EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.1 | cAMP-dependent protein kinase | - |
Homo sapiens | |
1.14.16.1 | cAMP-dependent protein kinase | - |
Rattus norvegicus | |
1.14.16.1 | lysolecithin | - |
Homo sapiens | |
1.14.16.1 | lysolecithin | - |
Rattus norvegicus | |
1.14.16.1 | additional information | relatively low activity with tetrahydrobiopterin can be selectively increased by limited proteolysis | Homo sapiens | |
1.14.16.1 | additional information | relatively low activity with tetrahydrobiopterin can be selectively increased by limited proteolysis | Rattus norvegicus | |
1.14.16.1 | additional information | enzyme activity is not stimulated by phosphorylation | Homo sapiens | |
1.14.16.1 | Phospholipids | activate | Homo sapiens | |
1.14.16.1 | Phospholipids | activate | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.16.1 | 0.0026 | - |
tetrahydrobiopterin | - |
Homo sapiens | |
1.14.16.1 | 0.033 | - |
6,7-dimethyltetrahydropterin | - |
Homo sapiens | |
1.14.16.1 | 0.05 | - |
phenylalanine | cofactor tetrahydrobiopterin | Homo sapiens | |
1.14.16.1 | 0.55 | - |
phenylalanine | cofactor dimethyltetrahydropterin | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.16.1 | 54000 | - |
2 * 54000, fetal liver enzyme, SDS-PAGE | Homo sapiens |
1.14.16.1 | 107000 | - |
fetal liver enzyme, sucrose density gradient centrifugation | Homo sapiens |
1.14.16.1 | 165000 | - |
gel filtration | Homo sapiens |
1.14.16.1 | 275000 | - |
- |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.16.1 | Homo sapiens | - |
- |
- |
1.14.16.1 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.14.16.1 | side-chain modification | - |
Homo sapiens |
1.14.16.1 | side-chain modification | enzyme contains 0.3 mol of phosphate per mol of enzyme subunit | Rattus norvegicus |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.16.1 | Phenyl-Sepharose, DEAE-Sepharose | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.16.1 | liver | - |
Homo sapiens | - |
1.14.16.1 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.16.1 | 0.106 | - |
- |
Homo sapiens |
EC Number | Storage Stability | Organism |
---|---|---|
1.14.16.1 | -80°C, enzyme concentration 1 mg/ml, several months, no loss of activity | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.16.1 | L-phenylalanine + 6,7-dimethyltetrahydrobiopterin | - |
Homo sapiens | L-tyrosine + 6,7-dimethyl-4a-hydroxy-tetrahydrobiopterin | - |
r | |
1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | relatively low activity with tetrahydrobiopterin can be selectively increased by limited proteolysis | Homo sapiens | L-tyrosine + dihydrobiopterin + H2O | - |
? | |
1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | relatively low activity with tetrahydrobiopterin can be selectively increased by limited proteolysis | Rattus norvegicus | L-tyrosine + dihydrobiopterin + H2O | - |
? | |
1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | low activity with tetrahydrobiopterin can be selectively increased by a wide variety of reversible and irreversible modificators of the enzyme, e.g. interaction with phospholipids | Homo sapiens | L-tyrosine + dihydrobiopterin + H2O | - |
? | |
1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | low activity with tetrahydrobiopterin can be selectively increased by a wide variety of reversible and irreversible modificators of the enzyme, e.g. interaction with phospholipids | Rattus norvegicus | L-tyrosine + dihydrobiopterin + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.16.1 | dimer | - |
Rattus norvegicus |
1.14.16.1 | dimer | 2 * 54000, fetal liver enzyme, SDS-PAGE | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.1 | tetrahydrobiopterin | - |
Homo sapiens | |
1.14.16.1 | tetrahydrobiopterin | - |
Rattus norvegicus |