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Literature summary extracted from

  • Klinman, J.P.; Krueger, M.
    Dopamine beta-hydroxylase: activity and inhibition in the presence of beta-substituted phenethylamines (1982), Biochemistry, 21, 67-75.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 2-chlorophenethylamine
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 1
-
3,4-Dihydroxyphenethylamine
-
Bos taurus
1.14.17.1 5.1
-
2-chlorophenethylamine
-
Bos taurus
1.14.17.1 24
-
2-hydroxyphenethylamine
-
Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.17.1 dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O mechanism Bos taurus
1.14.17.1 dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O stoichiometry Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 2-chlorophenethylamine + ascorbate + O2
-
Bos taurus 2-amino-1-chloro-1-phenylethanol + dehydroascorbate + H2O
-
?
1.14.17.1 2-hydroxyphenethylamine + ascorbate + O2
-
Bos taurus 2-amino-1-phenylethane-1,1-diol + dehydroascorbate + H2O
-
?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
?
1.14.17.1 additional information enzyme with very broad substrate specificity Bos taurus ?
-
?
1.14.17.1 octopamine + ascorbate + O2
-
Bos taurus ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.17.1 1.1
-
2-chlorophenethylamine
-
Bos taurus
1.14.17.1 4.2
-
2-hydroxyphenethylamine
-
Bos taurus
1.14.17.1 13
-
dopamine
-
Bos taurus