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Literature summary extracted from

  • May, S.W.; Mueller, P.W.; Padgette, S.R.; Herman, H.H.; Phillips, R.S.
    Dopamine-beta-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene (1983), Biochem. Biophys. Res. Commun., 110, 161-168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 1-Phenyl-1-aminomethylethene suicide inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 7
-
 Phenylethylamine
-
 Bos taurus
1.14.17.1 8.3
-
 1-Phenyl-1-aminomethylethene
-
 Bos taurus
1.14.17.1 14
-
 octopamine
-
 Bos taurus
1.14.17.1 20.4
-
 3-Phenylpropylamine
-
 Bos taurus
1.14.17.1 26.5
-
 phenyl 2-aminoethyl sulfide
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 Bos taurus enzyme plays a key role in the biosynthetic interconversion of neurotransmitters noradrenaline + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.1 additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 1-phenyl-1-aminomethylethene + ascorbate + O2 ascorbate and ferrocyanide can function as a electron donors Bos taurus 2,3-dihydroxy-2-phenylpropylamine + dehydroascorbate + H2O + ?
-
 ?
1.14.17.1 1-phenylethylamine + ascorbate + O2
-
 Bos taurus ?
-
 ?
1.14.17.1 2-phenylethylamine + ascorbate + O2
-
 Bos taurus ?
-
 ?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2 enzyme plays a key role in the biosynthetic interconversion of neurotransmitters Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.1 3-phenylpropylamine + ascorbate + O2
-
 Bos taurus ?
-
 ?
1.14.17.1 N-phenylethylenediamine + ascorbate + O2
-
 Bos taurus ?
-
 ?
1.14.17.1 octopamine + ascorbate + O2
-
 Bos taurus ?
-
 ?
1.14.17.1 phenyl 2-aminoethyl sulfide + ascorbate + O2
-
 Bos taurus phenyl-2-aminoethyl sulfoxide + dehydroascorbate + H2O
-
 ?
1.14.17.1 phenylaminoethyl sulfide + ascorbate + O2
-
 Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 dopamine-B-hydroxylase DBH Bos taurus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.17.1 10
-
 1-Phenyl-1-aminomethylethene
-
 Bos taurus
1.14.17.1 12
-
 3-Phenylpropylamine
-
 Bos taurus
1.14.17.1 33
-
 octopamine
-
 Bos taurus
1.14.17.1 65
-
 1-Phenylethylamine
-
 Bos taurus
1.14.17.1 68
-
 Phenylaminoethyl sulfide
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.1 13
-
 1-Phenyl-1-aminomethylethene
-
 Bos taurus