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Literature summary extracted from

  • Frigon, R.P.; Stone, R.A.
    Human plasma dopamine beta-hydroxylase. Purification and properties (1978), J. Biol. Chem., 253, 6780-6786.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.14.17.1 freezing and subsequent thawing results in rapid decrease of activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.1 0.8
-
ascorbate
-
Homo sapiens
1.14.17.1 2
-
tyramine
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.1 Cu2+ 4 atoms of tightly bound copper per tetramer Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.17.1 72000
-
4 * 72000 SDS-PAGE Homo sapiens
1.14.17.1 300000
-
dimeric form, SDS-PAGE Homo sapiens
1.14.17.1 610000
-
tetrameric form, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.14.17.1 glycoprotein
-
Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.17.1
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.1 additional information
-
-
Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.14.17.1 4°C, 0.5 M NaCl in 0.02 M sodium phosphate, pH 7.0, several weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 3,4-dihydroxyphenethylamine + ascorbate + O2
-
Homo sapiens noradrenaline + dehydroascorbate + H2O norepinephrine ?
1.14.17.1 tyramine + ascorbate + O2
-
Homo sapiens octopamine + dehydroascorbate + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.14.17.1 tetramer 4 * 72000 SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.17.1 5
-
pI: 5.8 Homo sapiens