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Literature summary extracted from

  • Scopsi, L.; Lee, R.; Gullo, M.; Collini, P.; Husten, E.J.; Eipper, B.A.
    Peptidylglycine alpha-amidating monooxygenase in neuroendocrine tumors: its identification, characterization, quantification, and relation to the grade of morphologic differentiation, amidated peptide content, and granin immunocytochemistry (1998), Appl. Immunohistochem., 6, 120-132.
No PubMed abstract available

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.3 membrane
-
 Homo sapiens 16020
-
1.14.17.3 secretory granule chromaffin granules Homo sapiens 30141
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.3 Cu2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.3 peptidylglycine + ascorbate + O2 Homo sapiens amidation of neurohormonal peptides peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.3 bronchial cancer cell
-
 Homo sapiens
-
1.14.17.3 gastric cancer cell
-
 Homo sapiens
-
1.14.17.3 gastrinoma cell
-
 Homo sapiens
-
1.14.17.3 intestinal cancer cell
-
 Homo sapiens
-
1.14.17.3 medullary thyroid carcinoma cell
-
 Homo sapiens
-
1.14.17.3 neuroendocrine tumor cell
-
 Homo sapiens
-
1.14.17.3 pancreatic cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.3 additional information
-
 peptidylglycine alpha-amidating and alpha-hydroxylating monooxygenase activities in several tumor tissue extracts, comparison with immunological analysis, overview, highest activity in medullary thyroid carcinoma Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2
-
 Homo sapiens alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2 COOH-terminal glycine Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?
1.14.17.3 peptidylglycine + ascorbate + O2 amidation of neurohormonal peptides Homo sapiens peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.3 ascorbate dependent on Homo sapiens