EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.17.3 | D-Tyr-Pro-Gly-Gly | inhibition of activity with D-Tyr-Val-Gly | Ovis aries | |
1.14.17.3 | D-Tyr-Val-Gly | inhibition of activity with D-Tyr-Pro-Gly | Ovis aries | |
1.14.17.3 | EDTA | - |
Ovis aries | |
1.14.17.3 | NaN3 | - |
Ovis aries | |
1.14.17.3 | p-hydroxymercuribenzoate | slightly | Ovis aries | |
1.14.17.3 | phosphate | - |
Ovis aries |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.17.3 | 0.033 | - |
D-Tyr-Pro-Gly-Gly | assayed without ascorbate and catalase, brain enzyme | Ovis aries | |
1.14.17.3 | 0.068 | - |
D-Tyr-Pro-Gly-Gly | assayed without ascorbate and catalase, pituitary enzyme | Ovis aries | |
1.14.17.3 | 0.075 | - |
D-Tyr-Pro-Gly-Gly | assayed with ascorbate and 0.1mg/ml catalase, pituitary enzyme | Ovis aries | |
1.14.17.3 | 0.289 | - |
D-Tyr-Pro-Gly-Gly | assayed with ascorbate and 0.1 mg/ml catalase, brain enzyme | Ovis aries |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.17.3 | secretory granule | synaptosomal and neurosecretory granules | Ovis aries | 30141 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.17.3 | Cu2+ | Cu2+ strongly stimulates activity | Ovis aries | |
1.14.17.3 | Cu2+ | a copper protein | Ovis aries |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.17.3 | peptidylglycine + ascorbate + O2 | Ovis aries | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.17.3 | Ovis aries | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.17.3 | hypothalamus | - |
Ovis aries | - |
1.14.17.3 | pituitary gland | - |
Ovis aries | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.17.3 | additional information | - |
very low activity in crude subcellular preparations | Ovis aries |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.17.3 | D-Tyr-Pro-Gly-Gly + ascorbate + O2 | synthetic peptide | Ovis aries | D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
1.14.17.3 | D-Tyr-Pro-Gly-Gly + ascorbate + O2 | optimal activity in sulfonic acid buffers | Ovis aries | D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
1.14.17.3 | D-Tyr-Val-Gly + ascorbate + O2 | - |
Ovis aries | D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
1.14.17.3 | peptidylglycine + ascorbate + O2 | - |
Ovis aries | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
1.14.17.3 | peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Ovis aries | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.17.3 | peptidylglycine alpha-amidating mono-oxygenase | - |
Ovis aries |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.17.3 | 7 | 8 | dependent on Cu2+-concentration | Ovis aries |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.17.3 | ascorbate | dependent on | Ovis aries |