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Literature summary extracted from

  • Gale, J.S.; McIntosh, J.E.A.; McIntosh, R.P.
    Peptidyl-glycine alpha-amidating mono-oxygenase activity towards a gonadotropin-releasing-hormone C-terminal peptide substrate, in subcellular fractions of sheep brain and pituitary (1988), Biochem. J., 251, 251-259.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.3 D-Tyr-Pro-Gly-Gly inhibition of activity with D-Tyr-Val-Gly Ovis aries
1.14.17.3 D-Tyr-Val-Gly inhibition of activity with D-Tyr-Pro-Gly Ovis aries
1.14.17.3 EDTA
-
Ovis aries
1.14.17.3 NaN3
-
Ovis aries
1.14.17.3 p-hydroxymercuribenzoate slightly Ovis aries
1.14.17.3 phosphate
-
Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.17.3 0.033
-
D-Tyr-Pro-Gly-Gly assayed without ascorbate and catalase, brain enzyme Ovis aries
1.14.17.3 0.068
-
D-Tyr-Pro-Gly-Gly assayed without ascorbate and catalase, pituitary enzyme Ovis aries
1.14.17.3 0.075
-
D-Tyr-Pro-Gly-Gly assayed with ascorbate and 0.1mg/ml catalase, pituitary enzyme Ovis aries
1.14.17.3 0.289
-
D-Tyr-Pro-Gly-Gly assayed with ascorbate and 0.1 mg/ml catalase, brain enzyme Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.17.3 secretory granule synaptosomal and neurosecretory granules Ovis aries 30141
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.17.3 Cu2+ Cu2+ strongly stimulates activity Ovis aries
1.14.17.3 Cu2+ a copper protein Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.17.3 peptidylglycine + ascorbate + O2 Ovis aries
-
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.3 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.3 hypothalamus
-
Ovis aries
-
1.14.17.3 pituitary gland
-
Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.17.3 additional information
-
very low activity in crude subcellular preparations Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.3 D-Tyr-Pro-Gly-Gly + ascorbate + O2 synthetic peptide Ovis aries D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O
-
?
1.14.17.3 D-Tyr-Pro-Gly-Gly + ascorbate + O2 optimal activity in sulfonic acid buffers Ovis aries D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O
-
?
1.14.17.3 D-Tyr-Val-Gly + ascorbate + O2
-
Ovis aries D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O
-
?
1.14.17.3 peptidylglycine + ascorbate + O2
-
Ovis aries peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?
1.14.17.3 peptidylglycine + ascorbate + O2 COOH-terminal glycine Ovis aries peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.17.3 peptidylglycine alpha-amidating mono-oxygenase
-
Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.17.3 7 8 dependent on Cu2+-concentration Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.17.3 ascorbate dependent on Ovis aries