Literature summary extracted from

Ramanadham, S.; Zhang, S.; Ma, Z.; Wohltmann, M.; Bohrer, A.; Hsu, F.F.; Turk, J.
DELTA6-, stearoyl CoA-, and DELTA5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations (2002), Biochim. Biophys. Acta, 1580, 40-56.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.19.3	human sequence determined	Homo sapiens
1.14.19.3	RT-PCR analysis of INS-1 beta-cell content of mRNA, primer pairs basedon known rat sequence	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.19.3	linoleic acid + AH2 + O2	Homo sapiens	important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid	gamma-linolenic acid + A + H2O	-	?
1.14.19.3	linoleic acid + AH2 + O2	Rattus norvegicus	important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid	gamma-linolenic acid + A + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.19.3	Homo sapiens	-	human	-
1.14.19.3	Rattus norvegicus	-	INS-1 beta-cells	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.19.3	linoleic acid + AH2 + O2	important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid	Homo sapiens	gamma-linolenic acid + A + H2O	-	?
1.14.19.3	linoleic acid + AH2 + O2	important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid	Rattus norvegicus	gamma-linolenic acid + A + H2O	-	?
1.14.19.3	linolenic acid + AH2 + O2	-	Homo sapiens	arachidonic acid + A + H2O	-	?
1.14.19.3	linolenic acid + AH2 + O2	-	Rattus norvegicus	arachidonic acid + A + H2O	-	?
1.14.19.3	octadeca-9,12-dienoic acid + AH2 + O2	-	Homo sapiens	gamma-linolenic acid + A + H2O	-	?
1.14.19.3	octadeca-9,12-dienoic acid + AH2 + O2	-	Rattus norvegicus	gamma-linolenic acid + A + H2O	-	?

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Release 2023.1 (January 2023)