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Literature summary extracted from
- Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series (1999), Lipids, 34, 23-30.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.3 | N-ethylmaleimide | n-3 DELTA6-desaturase is not inhibited, it increases, NEM specifically inhibits DELTA6-desaturase activity in the n-6 series, but not in the n-3-series | Homo sapiens |  |
| 1.14.19.3 | N-ethylmaleimide | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.3 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| 1.14.19.3 | microsome | membrane | Homo sapiens | - |
- |
| 1.14.19.3 | microsome | membrane | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.3 | linoleic acid + AH2 + O2 | Rattus norvegicus | - |
gamma-linolenic acid + A + H2O | - |
? | |
| 1.14.19.3 | linoleic acid + AH2 + O2 | Homo sapiens | key enzyme localized in the endoplasmic reticulum | gamma-linolenic acid + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.3 | Homo sapiens | - |
human | - |
| 1.14.19.3 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.3 | fetus | - |
Homo sapiens | - |
| 1.14.19.3 | fetus | - |
Rattus norvegicus | - |
| 1.14.19.3 | liver | - |
Rattus norvegicus | - |
| 1.14.19.3 | liver | fetal liver | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.3 | alpha-linolenic acid + AH2 + O2 | - |
Homo sapiens | stearidonic acid + A + 2 H2O | - |
? | |
| 1.14.19.3 | alpha-linolenic acid + AH2 + O2 | - |
Rattus norvegicus | stearidonic acid + A + 2 H2O | - |
? | |
| 1.14.19.3 | linoleic acid + AH2 + O2 | - |
Rattus norvegicus | gamma-linolenic acid + A + H2O | - |
? | |
| 1.14.19.3 | linoleic acid + AH2 + O2 | key enzyme localized in the endoplasmic reticulum | Homo sapiens | gamma-linolenic acid + A + H2O | - |
? | |
| 1.14.19.3 | octadeca-9,12-dienoic acid + AH2 + O2 | - |
Homo sapiens | gamma-linolenic acid + A + H2O | - |
? | |
| 1.14.19.3 | octadeca-9,12-dienoic acid + AH2 + O2 | - |
Rattus norvegicus | gamma-linolenic acid + A + H2O | - |
? | |
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