Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Meade, E.A.; Smith, W.L.; DeWitt, D.L.
    Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs (1993), J. Biol. Chem., 268, 6610-6614.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.1 6-methoxy-2-naphthyl acetic acid active metabolite of nabumetone, isozyme 1, 50% inhibition at 0.2-0.8 mM, isozyme 2, 50% inhibition at 0.015-0.55 mM Mus musculus
1.14.99.1 Acetylsalicylic acid isozyme 1, complete inhibition, isozyme 2, change in reaction, main product from arachidonate is 15-hydroxyeicosatetraenoic acid Mus musculus
1.14.99.1 docosahexaenoic acid isozyme 1, 50% inhibition at 0.011 mM, isozyme 2, 50% inhibition at 0.015 mM Mus musculus
1.14.99.1 flurbiprofen isozyme 1, 50% inhibition at 0.0005 mM, isozyme 2, 50% inhibition at 0.003 mM Mus musculus
1.14.99.1 Ibuprofen isozyme 1, 50% inhibition at 0.09 mM, isozyme 2, 50% inhibition at 0.008 mM Mus musculus
1.14.99.1 indomethacin isozyme 1, 50% inhibition at 0.005 mM, isozyme 2, 50% inhibition at 0.130-0.160 mM Mus musculus
1.14.99.1 Meclofenamic acid isozyme 1, 50% inhibition at 0.002 mM, isozyme 2, 50% inhibition at 0.015 mM Mus musculus
1.14.99.1 piroxicam isozyme 1, 50% inhibition at 0.075 mM, isozyme 2, 50% inhibition at 0.002 mM Mus musculus
1.14.99.1 sulindac sulfide isozyme 1, 50% inhibition at 0.0004 mM, isozyme 2, 50% inhibition at 0.012 mM Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Mus musculus
-
 recombinant enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonic acid + AH2 + 2 O2
-
 Mus musculus 15(R)-hydroxy-eicosatetraenoic acid + A + H2O product of aspirin treated enzyme ?